Mibampator

Modify Date: 2025-08-25 13:23:11

Mibampator structure	Common Name	Mibampator
	CAS Number	375345-95-2	Molecular Weight	438.604
	Density	1.2±0.1 g/cm3	Boiling Point	609.4±65.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₃₀N₂O₄S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	322.4±34.3 °C

Use of Mibampator

Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.

Name	N-[(2R)-2-[4-[4-[2-(methanesulfonamido)ethyl]phenyl]phenyl]propyl]propane-2-sulfonamide
Synonym	More Synonyms

Description	Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
Target	AMPA receptor[1].
In Vivo	Incubation of Mibampator (LY451395) with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species [1]. LY404187 and Mibampator (LY451395) reverses the central effects of an acutely intoxicating dose of ethanol in the rat. Mibampator (LY451395) significantly and dose-dependently reversed ethanol-induced deficits in both motor coordination and disruptions in an operant task where animals were trained to press a lever for food reward [2].
References	[1]. Zmijewski M, et al. Application of biocatalysis to drug metabolism: preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor potentiator using Actinoplanes missouriensis. Drug Metab Dispos. 2006 Jun;34(6):925-31. [2]. Jones N, et al. AMPA receptor potentiation can prevent ethanol-induced intoxication. Neuropsychopharmacology. 2008 Jun;33(7):1713-23.

Density	1.2±0.1 g/cm3
Boiling Point	609.4±65.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₀N₂O₄S₂
Molecular Weight	438.604
Flash Point	322.4±34.3 °C
Exact Mass	438.164703
PSA	109.10000
LogP	3.25
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.562
InChIKey	ULRDYYKSPCRXAJ-KRWDZBQOSA-N
SMILES	CC(CNS(=O)(=O)C(C)C)c1ccc(-c2ccc(CCNS(C)(=O)=O)cc2)cc1
Storage condition	2-8℃

N-[(2R)-2-(4-io...

CAS#:375345-98-5

[4-[2-(methanes...

CAS#:375346-00-2

~93%

Mibampator

CAS#:375345-95-2

Literature: Miller, William D.; Fray, Andrew H.; Quatroche, John T.; Sturgill, Christa D. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 359 - 364

N-carbamic acid...

CAS#:344462-93-7

N-[(2R)-2-(4-io...

CAS#:375345-98-5

~77%

Mibampator

CAS#:375345-95-2

Palladium

CAS#:7440-05-3

Literature: Arnold, Macklin Brian; Bleisch, Thomas John; Cuff, George William; Ornstein, Paul Leslie; Zimmerman, Dennis Michael Patent: US2003/225163 A1, 2003 ; Location in patent: Page 12-13 ;

N-[(2R)-2-(4-io...

CAS#:375345-98-5

[4-[2-(methanes...

CAS#:375346-00-2

~99%

Mibampator

CAS#:375345-95-2

N-[2-[4-[4-[2-(...

CAS#:516491-32-0

Literature: Miller, William D.; Fray, Andrew H.; Quatroche, John T.; Sturgill, Christa D. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 359 - 364

N-[2-[4-(4,4,5,...

CAS#:375345-99-6

Mibampator

CAS#:375345-95-2

Literature: Miller, William D.; Fray, Andrew H.; Quatroche, John T.; Sturgill, Christa D. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 359 - 364

N-[2-(4-iodophe...

CAS#:353235-93-5

Mibampator

CAS#:375345-95-2

Literature: Miller, William D.; Fray, Andrew H.; Quatroche, John T.; Sturgill, Christa D. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 359 - 364

Precursor 5
CAS#:375345-98-5 N-[(2R)-2-(4-io... CAS#:375346-00-2 [4-[2-(methanes... CAS#:344462-93-7 N-carbamic acid... CAS#:375345-99-6 N-[2-[4-(4,4,5,...
CAS#:353235-93-5 N-[2-(4-iodophe...
DownStream 0

Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1

Name: Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A4437

Name: Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2D6395

Name: Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2C9536

Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582

Name: Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A7681

Name: Cytotoxicity index (CI): selectivity for inhibition of SARS-CoV-2 induced cytotoxicit...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4303808

Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149

Name: Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentrati...
Source: ChEMBL
Target: Caco-2
External Id: CHEMBL4303807

Name: Enzymatic assay of human HDAC6 with custom peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808150

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Mibampator

UNII-A9V5BW73UU

N-[(2R)-2-(4'-{2-[(Methylsulfonyl)amino]ethyl}-4-biphenylyl)propyl]-2-propanesulfonamide

2-propanesulfonamide

LY451395

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Mibampator

Use of Mibampator

Names

Mibampator Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

MibampatorBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.