Mibampator

Modify Date: 2024-01-14 19:14:34

Mibampator Structure
Mibampator structure
 Common Name Mibampator
CAS Number 375345-95-2 Molecular Weight 438.604
Density 1.2±0.1 g/cm3 Boiling Point 609.4±65.0 °C at 760 mmHg
Molecular Formula C21H30N2O4S2 Melting Point N/A
MSDS N/A Flash Point 322.4±34.3 °C

 Use of Mibampator


Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.

 Names

Name N-[(2R)-2-[4-[4-[2-(methanesulfonamido)ethyl]phenyl]phenyl]propyl]propane-2-sulfonamide
Synonym More Synonyms

 Mibampator Biological Activity

Description Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
Related Catalog
Target

AMPA receptor[1].

In Vivo Incubation of Mibampator (LY451395) with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species [1]. LY404187 and Mibampator (LY451395) reverses the central effects of an acutely intoxicating dose of ethanol in the rat. Mibampator (LY451395) significantly and dose-dependently reversed ethanol-induced deficits in both motor coordination and disruptions in an operant task where animals were trained to press a lever for food reward [2].
References

[1]. Zmijewski M, et al. Application of biocatalysis to drug metabolism: preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor potentiator using Actinoplanes missouriensis. Drug Metab Dispos. 2006 Jun;34(6):925-31.

[2]. Jones N, et al. AMPA receptor potentiation can prevent ethanol-induced intoxication. Neuropsychopharmacology. 2008 Jun;33(7):1713-23.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 609.4±65.0 °C at 760 mmHg
Molecular Formula C21H30N2O4S2
Molecular Weight 438.604
Flash Point 322.4±34.3 °C
Exact Mass 438.164703
PSA 109.10000
LogP 3.25
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.562
Storage condition 2-8℃

 Synonyms

Mibampator
2-Propanesulfonamide, N-[(2R)-2-[4'-[2-[(methylsulfonyl)amino]ethyl][1,1'-biphenyl]-4-yl]propyl]-
UNII-A9V5BW73UU
N-[(2R)-2-(4'-{2-[(Methylsulfonyl)amino]ethyl}-4-biphenylyl)propyl]-2-propanesulfonamide
2-propanesulfonamide
LY451395
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