Mibampator

• 常用名: Mibampator
• 英文名: Mibampator
• CAS号: 375345-95-2
• 分子量: 438.604
• 密度: 1.2±0.1 g/cm3
• 沸点: 609.4±65.0 °C at 760 mmHg
• 分子式: C₂₁H₃₀N₂O₄S₂
• 熔点: N/A
• 闪点: 322.4±34.3 °C

Mibampator用途

Mibampator (LY451395)是AMPA受体高选择性增强剂。

Mibampator名称

• 中文名: Mibampator
• 英文名: N-[(2R)-2-[4-[4-[2-(methanesulfonamido)ethyl]phenyl]phenyl]propyl]propane-2-sulfonamide

Mibampator生物活性

• 描述: Mibampator (LY451395)是AMPA受体高选择性增强剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 靶点实验:

  AMPA receptor[1].

• 体内研究: Mibampator(LY451395)与Actinoplanes missouriensis NRRL B3342的孵育产生了几种代谢物,这些代谢物先前在临床前物种的体内代谢研究中被检测到[1]。 LY404187和Mibampator(LY451395)逆转了大鼠急性中毒剂量乙醇的中枢作用。 Mibampator(LY451395)在操作性任务中显着且剂量依赖性地逆转乙醇诱导的运动协调和中断缺陷,其中动物被训练以按压杠杆获得食物奖励[2]。
• 参考文献:

  [1]. Zmijewski M, et al. Application of biocatalysis to drug metabolism: preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor potentiator using Actinoplanes missouriensis. Drug Metab Dispos. 2006 Jun;34(6):925-31.

  [2]. Jones N, et al. AMPA receptor potentiation can prevent ethanol-induced intoxication. Neuropsychopharmacology. 2008 Jun;33(7):1713-23.

Mibampator物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 609.4±65.0 °C at 760 mmHg
• 分子式: C₂₁H₃₀N₂O₄S₂
• 分子量: 438.604
• 闪点: 322.4±34.3 °C
• 精确质量: 438.164703
• PSA: 109.10000
• LogP: 3.25
• InChIKey: ULRDYYKSPCRXAJ-KRWDZBQOSA-N
• SMILES: CC(CNS(=O)(=O)C(C)C)c1ccc(-c2ccc(CCNS(C)(=O)=O)cc2)cc1
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.562
• 储存条件: 2-8℃

Mibampator靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Cytotoxicity index (CI): selectivity for inhibition of SARS-CoV-2 induced cytotoxicit... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4303808

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentrati... 来源：ChEMBL 靶标：Caco-2 External Id：CHEMBL4303807

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

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Mibampator英文别名

• Mibampator
• UNII-A9V5BW73UU
• N-[(2R)-2-(4'-{2-[(Methylsulfonyl)amino]ethyl}-4-biphenylyl)propyl]-2-propanesulfonamide
• 2-propanesulfonamide
• LY451395