6-Hydroxykynurenic acid

Modify Date: 2025-08-26 01:54:06

6-Hydroxykynurenic acid Structure
6-Hydroxykynurenic acid structure
Common Name 6-Hydroxykynurenic acid
CAS Number 3778-29-8 Molecular Weight 205.16700
Density 1.569g/cm3 Boiling Point 455.6ºC at 760mmHg
Molecular Formula C10H7NO4 Melting Point N/A
MSDS N/A Flash Point 229.4ºC

 Use of 6-Hydroxykynurenic acid


6-Hydroxykynurenic acid (6-HKA) is a derivative of kynurenic acid (KYNA) and can be isolated from Ginkgo leaves. 6-Hydroxykynurenic acid is a low-affinity NMDAR antagonist (IC50: 59 μM)[1].

 Names

Name 6-hydroxy-4-oxo-1H-quinoline-2-carboxylic acid
Synonym More Synonyms

 6-Hydroxykynurenic acid Biological Activity

Description 6-Hydroxykynurenic acid (6-HKA) is a derivative of kynurenic acid (KYNA) and can be isolated from Ginkgo leaves. 6-Hydroxykynurenic acid is a low-affinity NMDAR antagonist (IC50: 59 μM)[1].
Related Catalog
Target

IC50: 59 μM (NMDAR)[1]

References

[1]. Weber M, et al. 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones. J Neurochem. 2001 May;77(4):1108-15.  

 Chemical & Physical Properties

Density 1.569g/cm3
Boiling Point 455.6ºC at 760mmHg
Molecular Formula C10H7NO4
Molecular Weight 205.16700
Flash Point 229.4ºC
Exact Mass 205.03800
PSA 90.39000
LogP 0.93190
Index of Refraction 1.681
InChIKey CQUUHDQRJWXDPY-UHFFFAOYSA-N
SMILES O=C(O)c1cc(=O)c2cc(O)ccc2[nH]1

 Safety Information

HS Code 2933499090

 Precursor & DownStream

Precursor  0

DownStream  1

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

6-Hydroxykynurenic acid
4,6-dihydroxy-2-carboxyquinoline
6-Hydroxykynureninsaeure
4,6-dihydroxy-quinoline-2-carboxylic acid
Quinaldic acid,4,6-dihydroxy
6-Hydroxykynurensaeure
6-Hydroxykynurenate
4,6-Dihydroxyquinaldic acid
4,6-Dihydroxy-chinolin-2-carbonsaeure
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