6-Hydroxykynurenic acid

• 常用名: 6-Hydroxykynurenic acid
• 英文名: 6-Hydroxykynurenic acid
• CAS号: 3778-29-8
• 分子量: 205.16700
• 密度: 1.569g/cm3
• 沸点: 455.6ºC at 760mmHg
• 分子式: C₁₀H₇NO₄
• 熔点: N/A
• 闪点: 229.4ºC

6-Hydroxykynurenic acid用途

6-Hydroxykynurenic acid (6-HKA) 是犬尿酸 (KYNA) 衍生物,能从银杏叶中分离得到。6-Hydroxykynurenic acid 是 NMDAR 的低亲和力拮抗剂 (IC50: 59 μM)。

6-Hydroxykynurenic acid名称

• 英文名: 6-hydroxy-4-oxo-1H-quinoline-2-carboxylic acid

6-Hydroxykynurenic acid生物活性

• 描述: 6-Hydroxykynurenic acid (6-HKA) 是犬尿酸 (KYNA) 衍生物,能从银杏叶中分离得到。6-Hydroxykynurenic acid 是 NMDAR 的低亲和力拮抗剂 (IC50: 59 μM)。
• 相关类别:
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> iGluR
• 靶点:

  IC50: 59 μM (NMDAR)[1]

• 参考文献:

  [1]. Weber M, et al. 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones. J Neurochem. 2001 May;77(4):1108-15.

6-Hydroxykynurenic acid物理化学性质

• 密度: 1.569g/cm3
• 沸点: 455.6ºC at 760mmHg
• 分子式: C₁₀H₇NO₄
• 分子量: 205.16700
• 闪点: 229.4ºC
• 精确质量: 205.03800
• PSA: 90.39000
• LogP: 0.93190
• InChIKey: CQUUHDQRJWXDPY-UHFFFAOYSA-N
• SMILES: O=C(O)c1cc(=O)c2cc(O)ccc2[nH]1
• 折射率: 1.681

6-Hydroxykynurenic acid安全信息

• 海关编码: 2933499090

6-Hydroxykynurenic acid海关

• 海关编码: 2933499090
• 中文概述: 2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-Hydroxykynurenic acid英文别名

• 6-Hydroxykynurenic acid
• 4,6-dihydroxy-2-carboxyquinoline
• 6-Hydroxykynureninsaeure
• 4,6-dihydroxy-quinoline-2-carboxylic acid
• Quinaldic acid,4,6-dihydroxy
• 6-Hydroxykynurensaeure
• 6-Hydroxykynurenate
• 4,6-Dihydroxyquinaldic acid
• 4,6-Dihydroxy-chinolin-2-carbonsaeure