(+)-Norfenfluramine hydrochloride structure
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Common Name | (+)-Norfenfluramine hydrochloride | ||
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CAS Number | 37936-89-3 | Molecular Weight | 239.66500 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C10H13ClF3N | Melting Point | N/A | |
MSDS | USA | Flash Point | N/A | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of (+)-Norfenfluramine hydrochloride(+)-Norfenfluramine hydrochloride, a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT2B receptor agonist (Ki: 11.2 nM). (+)-Norfenfluramine hydrochloride potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca2+. (+)-Norfenfluramine hydrochloride can be used for the research of primary pulmonary hypertension and valvular heart disease[1]. |
Name | (2S)-1-[3-(trifluoromethyl)phenyl]propan-2-amine,hydrochloride |
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Description | (+)-Norfenfluramine hydrochloride, a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT2B receptor agonist (Ki: 11.2 nM). (+)-Norfenfluramine hydrochloride potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca2+. (+)-Norfenfluramine hydrochloride can be used for the research of primary pulmonary hypertension and valvular heart disease[1]. |
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Related Catalog | |
Target |
5-HT2B Receptor:11.2 nM (Ki) 5-HT2C Receptor:324 nM (Ki) 5-HT2A Receptor:1516 nM (Ki) |
In Vitro | (+)-Norfenfluramine (1 nM to 100 μM) hydrochloride contracts arteries with a dramatic decrease in threshold (aorta and mesenteric resistance artery) in rats[1]. (+)-Norfenfluramine (1 and 10 μM, 3 min) hydrochloride induces contraction in aorta from tissues of normotensive and hypertensive rats[1]. (+)-Norfenfluramine (0-10 μM, 3 min) hydrochloride induces 5-HT release from rat hippocampal synaptosomes by Ca2+-dependent way [2]. |
In Vivo | (+)-Norfenfluramine (1-300 μg/kg, i.v.) hydrochloride induces pressor response in conscious SHAM and DOCA-salt rats[1]. (+)-Norfenfluramine (2.5 and 5 mg/kg, i.p.) hydrochloride decreases of 5-HT and 5-HIAA levels in telencephalon and brainstem of rats[3]. Animal Model: Conscious SHAM and DOCA-salt rats[1]. Dosage: 1-300 μg/kg Administration: Intravenous injection (i.v.), given in a cumulative fashion at 6-min intervals. Result: Induced pressor response in conscious SHAM and DOCA-salt rats. (change in mean arterial blood pressure at 300 μg/kg, mm Hg, SHAM vehicle=36, SHAM ketanserin=7, DOCA=51, DOCA ketanserin=19). |
References |
Molecular Formula | C10H13ClF3N |
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Molecular Weight | 239.66500 |
Exact Mass | 239.06900 |
PSA | 26.02000 |
LogP | 4.09740 |
Storage condition | 2-8°C |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
RIDADR | NONH for all modes of transport |