SI-2
Modify Date: 2024-01-14 18:24:10
SI-2 structure
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Common Name | SI-2 | ||
|---|---|---|---|---|
| CAS Number | 380537-35-9 | Molecular Weight | 265.313 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 459.9±37.0 °C at 760 mmHg | |
| Molecular Formula | C15H15N5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 231.9±26.5 °C | |
Use of SI-2SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2; selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells; significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model; "first-in-class" compound that targets oncogenic coactivator. |
| Name | SI-2 |
|---|---|
| Synonym | More Synonyms |
| Description | SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2; selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells; significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model; "first-in-class" compound that targets oncogenic coactivator. |
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| References | References 1. Song X, et al. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5. 2. Rohira AD, et al. Cancer Res. 2017 Aug 15;77(16):4293-4304. View Related Products by Target Other Targets |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 459.9±37.0 °C at 760 mmHg |
| Molecular Formula | C15H15N5 |
| Molecular Weight | 265.313 |
| Flash Point | 231.9±26.5 °C |
| Exact Mass | 265.132751 |
| LogP | 2.39 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.659 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
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| Ethanone, 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)- |
| (1E)-N-(1-Methyl-1H-benzoimidazol-2-yl)-N'-(1-pyridin-2-yl-ethylidene)-hydrazine |
| (1E)-1-(2-Pyridinyl)ethanone 1-(1-methyl-1H-benzoimidazol-2-yl)-hydrazone |
| 1-Methyl-2-{(2E)-2-[1-(2-pyridinyl)ethylidene]hydrazino}-1H-benzimidazole |
| SI-2 |