380537-35-9

380537-35-9 structure

Name: SI-2
Chemical Name: SI-2
CAS Number: 380537-35-9
Molecular Formula: C₁₅H₁₅N₅
Molecular Weight: 265.313
Create Date: 2020-01-11 19:37:33
Modify Date: 2025-08-25 16:39:03
SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2; selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells; significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model; "first-in-class" compound that targets oncogenic coactivator.

Name	SI-2
Synonyms	Ethanone, 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)- (1E)-N-(1-Methyl-1H-benzoimidazol-2-yl)-N'-(1-pyridin-2-yl-ethylidene)-hydrazine (1E)-1-(2-Pyridinyl)ethanone 1-(1-methyl-1H-benzoimidazol-2-yl)-hydrazone 1-Methyl-2-{(2E)-2-[1-(2-pyridinyl)ethylidene]hydrazino}-1H-benzimidazole SI-2

Description	SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2; selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells; significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model; "first-in-class" compound that targets oncogenic coactivator.
References	References 1. Song X, et al. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5. 2. Rohira AD, et al. Cancer Res. 2017 Aug 15;77(16):4293-4304. View Related Products by Target Other Targets

Hazard Codes	Xi