8-(Phenylmethoxy)guanosine

Modify Date: 2024-01-06 22:08:11

8-(Phenylmethoxy)guanosine Structure
8-(Phenylmethoxy)guanosine structure
Common Name 8-(Phenylmethoxy)guanosine
CAS Number 3868-36-8 Molecular Weight 389.36
Density 1.8g/cm3 Boiling Point 772ºC at 760mmHg
Molecular Formula C17H19N5O6 Melting Point N/A
MSDS N/A Flash Point 420.7ºC

 Use of 8-(Phenylmethoxy)guanosine


8-(Phenylmethoxy)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

 Names

Name 8-Benzyloxyguanosine
Synonym More Synonyms

 8-(Phenylmethoxy)guanosine Biological Activity

Description 8-(Phenylmethoxy)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog
References

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.  

 Chemical & Physical Properties

Density 1.8g/cm3
Boiling Point 772ºC at 760mmHg
Molecular Formula C17H19N5O6
Molecular Weight 389.36
Flash Point 420.7ºC
Exact Mass 389.13400
PSA 168.74000
Index of Refraction 1.796

 Synthetic Route

~%

8-(Phenylmethoxy)guanosine Structure

8-(Phenylmethox...

CAS#:3868-36-8

Literature: Slade, Peter G.; Priestley, Nigel D.; Sugden, Kent D. Organic Letters, 2007 , vol. 9, # 22 p. 4411 - 4414

~%

8-(Phenylmethoxy)guanosine Structure

8-(Phenylmethox...

CAS#:3868-36-8

Literature: Sheu; Foote Journal of the American Chemical Society, 1995 , vol. 117, # 24 p. 6439 - 6442

~%

8-(Phenylmethoxy)guanosine Structure

8-(Phenylmethox...

CAS#:3868-36-8

Literature: Nguyen, Khiem V.; Muller, James G.; Burrows, Cynthia J. Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2176 - 2180

 Synonyms

8-Benzyloxy-guanosin