Propynol Ethoxylate

Modify Date: 2024-01-04 12:03:57

Propynol Ethoxylate structure	Common Name	Propynol Ethoxylate
	CAS Number	3973-18-0	Molecular Weight	100.116
	Density	1.0±0.1 g/cm3	Boiling Point	168.7±15.0 °C at 760 mmHg
	Molecular Formula	C₅H₈O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	68.9±14.6 °C

Use of Propynol Ethoxylate

Propynol Ethoxylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Propynol Ethoxylate
Synonym	More Synonyms

Description	Propynol Ethoxylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.0±0.1 g/cm3
Boiling Point	168.7±15.0 °C at 760 mmHg
Molecular Formula	C₅H₈O₂
Molecular Weight	100.116
Flash Point	68.9±14.6 °C
Exact Mass	100.052429
PSA	29.46000
LogP	-0.25
Vapour Pressure	0.5±0.7 mmHg at 25°C
Index of Refraction	1.446
Storage condition	-20°C

Hazard Codes	Xi
Risk Phrases	36
Safety Phrases	26

Ethylene glycol

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3-Bromopropyne

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~60%

Propynol Ethoxylate

CAS#:3973-18-0

Literature: Kislukhin, Alexander A.; Higginson, Cody J.; Hong, Vu P.; Finn Journal of the American Chemical Society, 2012 , vol. 134, # 14 p. 6491 - 6497

tert-butyldimet...

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Propynol Ethoxylate

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Literature: RIB-X PHARMACEUTICALS, INC. Patent: WO2004/29066 A2, 2004 ; Location in patent: Page/Page column 281 ;

propynoic aldeh...

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~67%

Propynol Ethoxylate

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Literature: Bovicelli; Mincione; Patamia Synthetic Communications, 1991 , vol. 21, # 7 p. 907 - 913

3-Bromopropyne

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Propynol Ethoxylate

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Literature: Hoffmann-La Roche Inc. Patent: US6130239 A1, 2000 ; US 6130239 A

1-pentyn-5-ol

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2-Bromoethanol

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Propynol Ethoxylate

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Literature: Erver, Florian; Kuttner, Julian R.; Hilt, Gerhard Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8375 - 8385

Ethylene glycol

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3-Chloropropyne

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Propynol Ethoxylate

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Literature: Faure,R.; Descotes,G. Bulletin de la Societe Chimique de France, 1966 , p. 1569 - 1575 Full Text Show Details Bottini,A.T. et al. Journal of Organic Chemistry, 1965 , vol. 30, p. 2988 - 2994

ethylene glycol...

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Propynol Ethoxylate

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Literature: Atavin,A.S. et al. Journal of Organic Chemistry USSR (English Translation), 1967 , vol. 3, p. 10 - 12 Zhurnal Organicheskoi Khimii, 1967 , vol. 3, # 1 p. 12 - 15

sodium propargy...

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2-Chloroethanol

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Propynol Ethoxylate

CAS#:3973-18-0

Literature: Pola,J. et al. Collection of Czechoslovak Chemical Communications, 1978 , vol. 43, p. 760 - 768

Precursor 10
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DownStream 4
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