(S) FTY720 Phosphate
Modify Date: 2024-01-03 17:56:04
(S) FTY720 Phosphate structure
|
Common Name | (S) FTY720 Phosphate | ||
|---|---|---|---|---|
| CAS Number | 402616-26-6 | Molecular Weight | 387.451 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 584.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C19H34NO5P | Melting Point | 184-186ºC | |
| MSDS | USA | Flash Point | 307.1±32.9 °C | |
Use of (S) FTY720 PhosphateFTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. |
| Name | (S) FTY720 Phosphate |
|---|---|
| Synonym | More Synonyms |
| Description | FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. |
|---|---|
| Related Catalog | |
| Target |
S1PR1[1] |
| In Vitro | FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 µM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 µM) also reduces β-arrestin recruitment to S1PR1[1]. |
| In Vivo | FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice[1]. |
| Animal Admin | Mice[1]Male C57BL/6 (20-25 g) mice 8-10 weeks old receive a single intratracheal dose of bleomycin at 0.6 U/kg (or sterile saline) on Day 0 followed immediately by intraperitoneal injection of FTY720 (S)-Phosphate (0.5 mg/kg), FTY720 (0.5 mg/kg), or saline. Additional doses of FTY720 (S)-Phosphate or FTY720 are injected on Days 3 and 6. Bronchoalveolar lavage (BAL) fluid and lungs are then collected on Day 7. BAL fluid is used to detect BAL protein levels, WBC count, and WBC differential count. Lungs are perfused with saline to remove blood for Western blot, tissue albumin, and histopathology evaluation. Peripheral blood is obtained on Day 7 for examination of total cell counts and lymphocytes. Experiments are repeated 3 times. 6-10 mice are used per experimental group[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 584.2±60.0 °C at 760 mmHg |
| Melting Point | 184-186ºC |
| Molecular Formula | C19H34NO5P |
| Molecular Weight | 387.451 |
| Flash Point | 307.1±32.9 °C |
| Exact Mass | 387.217468 |
| PSA | 122.82000 |
| LogP | 4.27 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.541 |
| RIDADR | NONH for all modes of transport |
|---|
| Precursor 9 | |
|---|---|
| DownStream 0 | |
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| 1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, mono(dihydrogen phosphate) (ester), (2S)- |
| (S)-2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol mono(dihydrogenphosphate) ester |
| (2S)-2-Amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl dihydrogen phosphate |
| FTY720 (S)-Phosphate |
| fingolimod-P |
| 1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, mono(dihydrogen phosphate) (ester) |
| (S)-FTY720-P |
| 2-Amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl dihydrogen phosphate |
| 2-(S)-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Mono(dihydrogen phosphate) Ester |
| (S)-FTY720 |
| 2-ammonio-2-(hydroxymethyl)-4-(4-octylphenyl)butyl hydrogen phosphate |
| (S)-FTY720-phosphate |
| [14C]-(S)-FTY720P |