BTO-1
BTO-1 structure
|
Common Name | BTO-1 | ||
|---|---|---|---|---|
| CAS Number | 40647-02-7 | Molecular Weight | 264.21700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H4N4O4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of BTO-1BTO-1 is a Polo-like kinase (Plk) inhibitor. BTO-1 is primarily used for phosphorylation and dephosphorylation applications[1][2]. |
| Name | 5-cyano-7-nitro-3-oxido-1,3-benzothiazol-3-ium-2-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | BTO-1 is a Polo-like kinase (Plk) inhibitor. BTO-1 is primarily used for phosphorylation and dephosphorylation applications[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Plx1 |
| In Vitro | BTO-1 (50 μM; 4 hours; U20S cells) results in monopolar spindles in a comparable fraction of mitotic cells. BTO-1(20 μM; 1 hour; PTK cells) shows a dose-dependent reduction in phospho-Cdc25C. BTO-1(25 μM; 1 hour; PTK cells) shows about 20 % reduction in H3 phosphorylation compared to control cells. BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring[1][2]. |
| References |
| Molecular Formula | C9H4N4O4S |
|---|---|
| Molecular Weight | 264.21700 |
| Exact Mass | 263.99500 |
| PSA | 166.40000 |
| LogP | 2.43208 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H315-H319-H332-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 20/21/22-36/37/38 |
| Safety Phrases | 26-36/37 |
| RIDADR | NONH for all modes of transport |
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~%
BTO-1 CAS#:40647-02-7 |
| Literature: Wagner,K. et al. Chemische Berichte, 1973 , vol. 106, p. 640 - 654 |
| Precursor 1 | |
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| DownStream 0 | |
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Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Mol. Cell. 45 , 371-383, (2012) Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusiv... |
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Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance.
Nat. Chem. Biol. 2 , 608-617, (2006) Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and fo... |
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Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells.
Curr. Chem. Genomics 5 , 21-9, (2011) Tumor Necrosis Factor-α (TNF-α), a secreted cytokine, plays an important role in inflammatory diseases and immune disorders, and is a potential target for drug development. The traditional assays for ... |
| BTO-1 |
| 5-cyano-7-nitro-3-oxy-benzothiazole-2-carboxylic acid amide |
| HMS3260F21 |
| HMS3229L17 |
| 5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide |