BTO-1
BTO-1 structure
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Common Name | BTO-1 | ||
|---|---|---|---|---|
| CAS Number | 40647-02-7 | Molecular Weight | 264.21700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H4N4O4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Mol. Cell. 45 , 371-383, (2012) Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusive. Here, we report that Polo-like kinase 1 (Plk1), which is... |
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Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance.
Nat. Chem. Biol. 2 , 608-617, (2006) Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and for developing antitumor agents. Guided by homology modeling ... |
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Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells.
Curr. Chem. Genomics 5 , 21-9, (2011) Tumor Necrosis Factor-α (TNF-α), a secreted cytokine, plays an important role in inflammatory diseases and immune disorders, and is a potential target for drug development. The traditional assays for detecting TNF-α, enzyme linked immunosorbent assay (ELISA) ... |
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The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells.
PLoS Biol. 8 , (2010) The protozoan parasite Theileria inhabits the host cell cytoplasm and possesses the unique capacity to transform the cells it infects, inducing continuous proliferation and protection against apoptosis. The transforming schizont is a multinucleated syncytium ... |
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Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
PLoS Biol. 7 , e1000111, (2009) Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation relies on positional cues provided by... |