piperaquine phosphate

Modify Date: 2024-01-02 19:32:18

piperaquine phosphate structure	Common Name	piperaquine phosphate
	CAS Number	4085-31-8	Molecular Weight	535.511
	Density	1.3±0.1 g/cm3	Boiling Point	721.1±60.0 °C at 760 mmHg
	Molecular Formula	C₂₉H₃₂Cl₂N₆	Melting Point	198-200°C (lit.)
	MSDS	N/A	Flash Point	389.9±32.9 °C

Use of piperaquine phosphate

Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[1][2].

Name	Piperaquine phosphate
Synonym	More Synonyms

Description	Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[1][2].
Related Catalog	Research Areas >> Infection
In Vivo	Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1]. Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1].
References	[1]. Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11. [2]. Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87.

Density	1.3±0.1 g/cm3
Boiling Point	721.1±60.0 °C at 760 mmHg
Melting Point	198-200°C (lit.)
Molecular Formula	C₂₉H₃₂Cl₂N₆
Molecular Weight	535.511
Flash Point	389.9±32.9 °C
Exact Mass	534.206543
PSA	38.74000
LogP	5.15
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.664

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC3280000

CHEMICAL NAME :: Quinoline, 4,4'-(trimethylenedi-4,1-piperazinediyl)bis(7-chloro-

CAS REGISTRY NUMBER :: 4085-31-8

BEILSTEIN REFERENCE NO. :: 0905079

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C29-H32-Cl2-N6

MOLECULAR WEIGHT :: 535.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1098 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,273,1986

Hazard Codes	Xi
HS Code	2942000000

Precursor 3
CAS#:109-64-8 1,3-Dibromopropane CAS#:837-52-5 7-Chloro-4-(pip... CAS#:86-98-6 4,7-Dichloroqui...
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis[7-chloro-

4,4'-(propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline)

Piperaquine tetraphosphate tetrahydrate

7-Chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline

Piperaquine

piperaquinoline

PIRERAQUINE PHOSPHATE

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline)

DC Chemicals Limited
China
Product Name: Piperaquine Phosphate
Price: $250.0/100mg $600.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Piperaquine phosphate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Piperaquine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Piperaquine phosphate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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piperaquine phosphate

Use of piperaquine phosphate

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