1-(2,3-DICHLOROPHENYL)PIPERAZINE

Modify Date: 2025-08-22 11:13:10

1-(2,3-DICHLOROPHENYL)PIPERAZINE structure	Common Name	1-(2,3-DICHLOROPHENYL)PIPERAZINE
	CAS Number	41202-77-1	Molecular Weight	231.122
	Density	1.3±0.1 g/cm3	Boiling Point	365.1±42.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₂Cl₂N₂	Melting Point	242-244ºC
	MSDS	N/A	Flash Point	174.6±27.9 °C

Use of 1-(2,3-DICHLOROPHENYL)PIPERAZINE

DCPP is a potent inhibitor of DHCR7, which is known as the last enzyme in cholesterol biosynthesis.

Name	1-(2,3-dichlorophenyl)piperazine
Synonym	More Synonyms

Density	1.3±0.1 g/cm3
Boiling Point	365.1±42.0 °C at 760 mmHg
Melting Point	242-244ºC
Molecular Formula	C₁₀H₁₂Cl₂N₂
Molecular Weight	231.122
Flash Point	174.6±27.9 °C
Exact Mass	230.037750
PSA	15.27000
LogP	2.89
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.570
InChIKey	UDQMXYJSNNCRAS-UHFFFAOYSA-N
SMILES	Clc1cccc(N2CCNCC2)c1Cl

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
Product Name: 1-(2,3-Dichlorophenyl)piperazine
Synonyms:

Section2. Hazards identiﬁcation
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:1-(2,3-Dichlorophenyl)piperazine
CAS number:41202-77-1

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not speciﬁed
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C10H12Cl2N2
Molecular weight:231.1

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26
HS Code	2933599090

2,3-Dichloroaniline

CAS#:608-27-5

dea

CAS#:111-42-2

~30%

1-(2,3-DICHLORO...

CAS#:41202-77-1

Literature: Robarge; Husbands; Kieltyka; Brodbeck; Thurkauf; Newman Journal of Medicinal Chemistry, 2001 , vol. 44, # 19 p. 3175 - 3186

Piperazine

CAS#:110-85-0

2,3-dichlorobro...

CAS#:56961-77-4

1-(2,3-DICHLORO...

CAS#:41202-77-1

Literature: Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-Ichi Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 12 p. 4023 - 4027

Precursor 4
CAS#:608-27-5 2,3-Dichloroaniline CAS#:111-42-2 dea CAS#:110-85-0 Piperazine CAS#:56961-77-4 2,3-dichlorobro...
DownStream 6
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CAS#:90096-40-5 2-[4-(2,3-dichl... CAS#:486393-38-8 4-[4-(2,3-dichl...

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity

Name: Partial agonist activity at human D2S receptor expressed in HEK293T cells coexpressin...
Source: ChEMBL
Target: D(2) dopamine receptor
External Id: CHEMBL2167814

Name: Partial agonist activity at human D3 receptor expressed in HEK293T cells coexpressing...
Source: ChEMBL
Target: D(3) dopamine receptor
External Id: CHEMBL2167813

Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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