Aripiprazole

Modify Date: 2024-01-02 10:43:19

Aripiprazole Structure
Aripiprazole structure
Common Name Aripiprazole
CAS Number 129722-12-9 Molecular Weight 448.385
Density 1.3±0.1 g/cm3 Boiling Point 646.2±55.0 °C at 760 mmHg
Molecular Formula C23H27Cl2N3O2 Melting Point 139°C
MSDS Chinese USA Flash Point 344.6±31.5 °C
Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger

 Use of Aripiprazole


Aripiprazole(Abilify) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM. IC50 Value: 4.2 nM(Ki)Target: 5-HT ReceptorAripiprazole is an atypical antipsychotic medication used for the treatment of schizophrenia. It has also recently received FDA approval for the treatment of acute manic and mixed episodes associated with bipolar disorder. Aripiprazole appears to mediate its antipsychotic effects primarily by partial agonism at the D2 receptor. In addition to partial agonist activity at the D2 receptor, aripiprazole is also a partial agonist at the 5-HT1A receptor, and like the other atypical antipsychotics, aripiprazole displays an antagonist profile at the 5-HT2A receptor. Aripiprazole has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.

 Names

Name aripiprazole
Synonym More Synonyms

 Aripiprazole Biological Activity

Description Aripiprazole(Abilify) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM. IC50 Value: 4.2 nM(Ki)Target: 5-HT ReceptorAripiprazole is an atypical antipsychotic medication used for the treatment of schizophrenia. It has also recently received FDA approval for the treatment of acute manic and mixed episodes associated with bipolar disorder. Aripiprazole appears to mediate its antipsychotic effects primarily by partial agonism at the D2 receptor. In addition to partial agonist activity at the D2 receptor, aripiprazole is also a partial agonist at the 5-HT1A receptor, and like the other atypical antipsychotics, aripiprazole displays an antagonist profile at the 5-HT2A receptor. Aripiprazole has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.
Related Catalog
References

[1]. Stip E, Tourjman V. et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20.

[2]. Burris KD, Molski TF, Xu C et al. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):381-9.

[3]. Swainston Harrison T, Perry CM. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs. 2004;64(15):1715-36.

[4]. Nagasaka Y, Oda K, Iwatsubo T, Kawamura A, Usui T.Nagasaka Y, Oda K, Iwatsubo T, Kawamura A, Usui T.Effects of aripiprazole and its active metabolite dehydroaripiprazole on the activities of drug efflux transporters expressed both in the intestine and at the blood-brain barrier.Biopharm Drug Dispos. 2012 Jul 27. doi: 10.1002/bdd.1801.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 646.2±55.0 °C at 760 mmHg
Melting Point 139°C
Molecular Formula C23H27Cl2N3O2
Molecular Weight 448.385
Flash Point 344.6±31.5 °C
Exact Mass 447.148041
PSA 44.81000
LogP 5.59
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.593
Storage condition -20°C Freezer

 Safety Information

Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H301 + H311 + H331-H370
Precautionary Statements Missing Phrase - N15.00950417-P261-P280-P302 + P352 + P312-P304 + P340 + P312-P403 + P233
Hazard Codes F,Xn
Risk Phrases 11-20/21/22-36
Safety Phrases S26-S36
RIDADR UN 1993C 3 / PGIII
WGK Germany 3
HS Code 2933790090

 Synthetic Route

 Customs

HS Code 2933790090
Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

 Articles49

More Articles
Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range.

J. Pharmacol. Sci. 127(3) , 326-31, (2015)

Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human stud...

In vivo pharmacological characterization of TAK-063, a potent and selective phosphodiesterase 10A inhibitor with antipsychotic-like activity in rodents.

J. Pharmacol. Exp. Ther. 352(3) , 471-9, (2015)

Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP phosphodiesterase highly expressed in medium spiny neurons (MSNs) in the striatum. We evaluated the in vivo pharmacological profile of a potent and select...

The use of dried blood spots for quantification of 15 antipsychotics and 7 metabolites with ultra-high performance liquid chromatography - tandem mass spectrometry.

Drug Test. Anal. 7 , 502-11, (2015)

Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alte...

 Synonyms

7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
2(1H)-quinolinone, 7-4-4-(2,3-dichlorophenyl)-1-piperazinylbutoxy-3,4-dihydro-
Abilify
2(1H)-Quinolinone, 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-
7-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone
7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
UNII-82VFR53I78
7-{4-4-(2,3-dichlorophenyl)piperazin-1-ylbutoxy}-3,4-dihydroquinolin-2(1H)-one
Aripiprazole
7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
EINECS 200-835-2
MFCD00892072
Top Suppliers:I want be here




Get all suppliers and price by the below link:

Aripiprazole suppliers


Price: ¥156.5/5g

Reference only. check more Aripiprazole price