5-Nitro-1,10-phenanthroline

Modify Date: 2024-01-02 20:18:46

5-Nitro-1,10-phenanthroline structure	Common Name	5-Nitro-1,10-phenanthroline
	CAS Number	4199-88-6	Molecular Weight	225.203
	Density	1.4±0.1 g/cm3	Boiling Point	444.0±30.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₇N₃O₂	Melting Point	202-204 °C(lit.)
	MSDS	Chinese USA	Flash Point	222.3±24.6 °C
	Symbol	GHS07	Signal Word	Warning

Use of 5-Nitro-1,10-phenanthroline

5-Nitro-1,10-phenanthroline (5-NP), is a o-Phenanthroline (HY-W004544) derivative, as a mediator of glucose oxidase (GOX) with antituberculous activity. 5-Nitro-1,10-phenanthroline can be applied as redox mediators for oxidases and is suitable for the development of reagent-less biosensors and biofuel cells[1][1].

Name	5-Nitro-1,10-phenanthroline
Synonym	More Synonyms

Description	5-Nitro-1,10-phenanthroline (5-NP), is a o-Phenanthroline (HY-W004544) derivative, as a mediator of glucose oxidase (GOX) with antituberculous activity. 5-Nitro-1,10-phenanthroline can be applied as redox mediators for oxidases and is suitable for the development of reagent-less biosensors and biofuel cells[1][1].
Related Catalog	Research Areas >> Infection
In Vitro	5-Nitro-1,10-phenanthroline (25 μM; 24 h) kills naturally resistant intracellular bacteria by inducing autophagy in THP-1 macrophages[2]. 5-Nitro-1,10-phenanthroline (1x, 5x, 20x or 50x MIC, MIC=0.78 μM; 1 h) also modulates the host machinery to kill intracellular pathogens by inhibiting mycolic acid biosynthesis of Mtb[2]. Cell Viability Assay[2] Cell Line: Mtb H37Rv, M. bovis BCG and M. bovis BCG-5NP resistant strain Concentration: 0-12.5 μM Incubation Time: 24 hours Result: Inhibited pathogens with MIC99 values of 0.78 μM (Mtb H37Rv), 0.78 μM (M. bovis BCG), and >12.5 μM (M. bovis BCG-5NP), respectively.

Density	1.4±0.1 g/cm3
Boiling Point	444.0±30.0 °C at 760 mmHg
Melting Point	202-204 °C(lit.)
Molecular Formula	C₁₂H₇N₃O₂
Molecular Weight	225.203
Flash Point	222.3±24.6 °C
Exact Mass	225.053833
PSA	71.60000
LogP	1.56
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.768
Water Solubility	insoluble

5-Nitro-1,10-phenanthroline MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

1,10-Phenanthroline

CAS#:66-71-7

~98%

5-Nitro-1,10-ph...

CAS#:4199-88-6

Literature: Ji, Shaomin; Guo, Huimin; Yuan, Xiaolin; Li, Xiaohuan; Ding, Haidong; Gao, Peng; Zhao, Chunxia; Wu, Wenting; Wu, Wanhua; Zhao, Jianzhang Organic Letters, 2010 , vol. 12, # 12 p. 2876 - 2879

o-Phenanthrolin...

CAS#:5144-89-8

~42%

5-Nitro-1,10-ph...

CAS#:4199-88-6

Literature: Nisshinbo Industries, Inc. Patent: US5856479 A1, 1999 ;

1,10-Phenanthroline

CAS#:66-71-7

~0%

1,10-Phenanthro...

CAS#:27318-90-7

5-Nitro-1,10-ph...

CAS#:4199-88-6

Literature: Amouyal, Edmond; Homsi, Abdulrazzak; Chambron, Jean-Claude; Sauvage, Jean-Pierre Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1990 , # 6 p. 1841 - 1845

o-Phenylenediamine

CAS#:95-54-5

5-Nitro-1,10-ph...

CAS#:4199-88-6

Literature: Halcrow; Kermack Journal of the Chemical Society, 1946 , p. 155

8-amino-5-nitro...

CAS#:42606-38-2

Glycerol

CAS#:56-81-5

5-Nitro-1,10-ph...

CAS#:4199-88-6

Literature: Halcrow; Kermack Journal of the Chemical Society, 1946 , p. 155

1,10-Phenanthroline

CAS#:66-71-7

Sulfuric acid

CAS#:7664-93-9

Sulfur trioxide

CAS#:7446-11-9

nitric acid

CAS#:7697-37-2

Detail

Literature: Inglett; Smith Journal of the American Chemical Society, 1950 , vol. 72, p. 842

1,10-Phenanthroline

CAS#:66-71-7

Sulfuric acid

CAS#:7664-93-9

Sulfur trioxide

CAS#:7446-11-9

nitric acid

CAS#:7697-37-2

Detail

Literature: Smith; Cagle Journal of Organic Chemistry, 1947 , vol. 12, p. 781,782

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

The effect of ancillary ligand chirality and phenanthroline functional group substitution on the cytotoxicity of platinum(II)-based metallointercalators.

J. Inorg. Biochem. 101 , 1049-1058, (2007)

Fifteen platinum(II)-based metallointercalators have been synthesised that utilise substituted 1,10-phenanthroline (phen) ligands, including 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10-phe...

5-nitro-1,10-phenenthroline

1,10-Phenanthroline, 5-nitro-

5-Nitro-1,10-phenanthroline

5-Nitro-1,10-diazaphenanthrene

EINECS 224-097-6

5-nitro-1,10-phenantroline

1,10-Phenanthroline,5-nitro

Nitroferroin

MFCD00004981