5-Methoxyflavone
Modify Date: 2024-01-06 19:00:38
5-Methoxyflavone structure
|
Common Name | 5-Methoxyflavone | ||
|---|---|---|---|---|
| CAS Number | 42079-78-7 | Molecular Weight | 252.26500 | |
| Density | 1.24g/cm3 | Boiling Point | 422.5ºC at 760mmHg | |
| Molecular Formula | C16H12O3 | Melting Point | 131-133°C | |
| MSDS | N/A | Flash Point | 201.1ºC | |
Use of 5-Methoxyflavone5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors. |
| Name | 5-Methoxyflavone |
|---|---|
| Synonym | More Synonyms |
| Description | 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors. |
|---|---|
| Related Catalog | |
| Target |
DNA polymerase-beta[1]. |
| In Vitro | 5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. 5-methoxyflavone (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate[1]. 5-Methoxyflavone (5-MF, 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 (DR5) in a time-dependent manner[2]. |
| In Vivo | 5-Methoxyflavone (100, 150 mg/kg, i.p) significantly decreases the latency time to loss of righting reflex. 5-Methoxyflavone (50, 100 and 150 mg/kg, i.p) exhibits a significant and dose-dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, i.p) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, i.p) completely abolishesed the grooming response similar to diazepam treated animals[3]. |
| References |
| Density | 1.24g/cm3 |
|---|---|
| Boiling Point | 422.5ºC at 760mmHg |
| Melting Point | 131-133°C |
| Molecular Formula | C16H12O3 |
| Molecular Weight | 252.26500 |
| Flash Point | 201.1ºC |
| Exact Mass | 252.07900 |
| PSA | 39.44000 |
| LogP | 3.46860 |
| Index of Refraction | 1.548 |
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36/37/39 |
| WGK Germany | 3 |
| HS Code | 2914509090 |
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
| 5-methoxy-2-phenylchromen-4-one |
| MFCD00016942 |
| EINECS 255-652-0 |
| 5-METHOXYFLAVONE |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: 5-Methoxyflavone
- Price: Click To Check
- Purity: 95.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- BioBioPha
- China
- Product Name: 5-Methoxyflavone
- Price: ￥Inquiry/5mg
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Xueping-Zheng
- Email: 1477035482@qq.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 5-Methoxyflavone
- Price: ￥1808.0/100mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: 5-Methoxyflavone
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: 5-Methoxyflavone
- Price: $100.0/100mg $200.0/250mg $400.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 5-methoxyflavone
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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Price: ￥550/10 mM * 1 mL in DMSO
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