2,2',4'-Trichloroacetophenone

Modify Date: 2024-01-02 12:16:38

2,2',4'-Trichloroacetophenone Structure
2,2',4'-Trichloroacetophenone structure
Common Name 2,2',4'-Trichloroacetophenone
CAS Number 4252-78-2 Molecular Weight 223.484
Density 1.4±0.1 g/cm3 Boiling Point 292.2±25.0 °C at 760 mmHg
Molecular Formula C8H5Cl3O Melting Point 47-54 °C(lit.)
MSDS Chinese USA Flash Point 122.1±23.7 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Names

Name 2,2',4'-Trichloroacetophenone
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 292.2±25.0 °C at 760 mmHg
Melting Point 47-54 °C(lit.)
Molecular Formula C8H5Cl3O
Molecular Weight 223.484
Flash Point 122.1±23.7 °C
Exact Mass 221.940598
PSA 17.07000
LogP 2.97
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.565
Water Solubility 60 mg/L (20 ºC)

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H317-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes T:Toxic
Risk Phrases R23/24/25;R34;R51/53
Safety Phrases S26-S36/37/39-S61-S45-S37/39
RIDADR 1759
WGK Germany 3
Packaging Group III
Hazard Class 8
HS Code 29147090

 Synthetic Route

~75%

2,2',4'-Trichloroacetophenone Structure

2,2',4'-Trichlo...

CAS#:4252-78-2

Literature: Prakash, G.K. Sxurya; Ismail, Rehana; Garcia, Jessica; Panja, Chiradeep; Rasul, Golam; Mathew, Thomas; Olah, George A. Tetrahedron Letters, 2011 , vol. 52, # 11 p. 1217 - 1221

~%

2,2',4'-Trichloroacetophenone Structure

2,2',4'-Trichlo...

CAS#:4252-78-2

Literature: Zhan, Peng; Liu, Xinyong; Cao, Yuan; Wang, Yan; Pannecouque, Christophe; De Clercq, Erik Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5368 - 5371

~%

2,2',4'-Trichloroacetophenone Structure

2,2',4'-Trichlo...

CAS#:4252-78-2

Literature: Pilgram,K. et al. Journal of Organic Chemistry, 1969 , vol. 34, p. 3558 - 3561

~90%

2,2',4'-Trichloroacetophenone Structure

2,2',4'-Trichlo...

CAS#:4252-78-2

Literature: Kim, Hak Jin; Kim, Hyoung Rae; Ryu, Eung K. Synthetic Communications, 1990 , vol. 20, # 11 p. 1625 - 1629

~%

2,2',4'-Trichloroacetophenone Structure

2,2',4'-Trichlo...

CAS#:4252-78-2

Literature: Pilgram,K. et al. Journal of Organic Chemistry, 1969 , vol. 34, p. 3558 - 3561

~%

2,2',4'-Trichloroacetophenone Structure

2,2',4'-Trichlo...

CAS#:4252-78-2

Literature: Liu, Hui-Ling; Li, Zongcheng; Anthonsen, Thorleif Molecules, 2000 , vol. 5, # 9 p. 1055 - 1061

~%

2,2',4'-Trichloroacetophenone Structure

2,2',4'-Trichlo...

CAS#:4252-78-2

Literature: Kunckell Chemische Berichte, 1907 , vol. 40, p. 1703

 Customs

HS Code 2914700090
Summary HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

 Articles2

More Articles
Glutathione-dependent reductive dehalogenation of 2,2',4'-trichloroacetophenone to 2',4'-dichloroacetophenone.

Biochem. Pharmacol. 31(23) , 3885-90, (1982)

alpha-Haloketones are highly reactive compounds, which are known to undergo enzymatic reduction to methyl ketones. The objective of this research was to characterize the enzymes involved in this react...

Clean and efficient microwave-solvent-free synthesis of 1-(2', 4'-dichlorophenacyl) azoles. Pérez ER, et al.

Tetrahedron 59(6) , 865-70, (2003)

 Synonyms

A,2,4-TRICHLOROACETOPHENONE
MFCD00000934
ω,2,4-Trichloroacetophenone
2,4-dichlorophenyl chloromethyl ketone
EINECS 224-218-2
2,2',4'-trichloro acetophenone
TRICHLOROACETOPHENON
2,4,W-Trichloroacetophenon
2-Chloro-1-(2,4-dichlorophenyl)ethanone
2,4-Dichlorophenacyl Chloride
2,4-dichlorphenacylchloride
2,2',4'-Trichloroacetophenone
TRICHLOROACETOPHENONE
2,2,4,6-TETRACHLORO-2,2-DIHYDRO-1,3,5,2-TRIAZAPHOSPHORINE
Ethanone, 2-chloro-1-(2,4-dichlorophenyl)-
G1VR BG DG