N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)

Modify Date: 2024-09-13 19:45:48

N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1) structure	Common Name	N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)
	CAS Number	4299-60-9	Molecular Weight	372.44000
	Density	N/A	Boiling Point	482.2ºC at 760 mmHg
	Molecular Formula	C₁₅H₂₄N₄O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	245.4ºC

Use of N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)

Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].

Name	4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide,2-(2-hydroxyethylamino)ethanol
Synonym	More Synonyms

Description	Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Endocrinology Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Signaling Pathways >> Anti-infection >> Bacterial
Target	ETA:0.60 μM (IC50) ETB:22 μM (IC50)
References	[1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34. [2]. Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387.

Boiling Point	482.2ºC at 760 mmHg
Molecular Formula	C₁₅H₂₄N₄O₅S
Molecular Weight	372.44000
Flash Point	245.4ºC
Exact Mass	372.14700
PSA	159.09000
LogP	2.36090

NU-445

N-(3,4-Dimethylisoxazol-5-yl)sulphanilamide,compound with 2,2'-iminodiethanol (1:1)

Sulfafurazol 2,2'-imidodiethanol

Benzenesulfonamide,4-amino-N-(3,4-dimethyl-5-isoxazolyl)-,compd. with 2,2'-iminobis(ethanol) (1:1)

EINECS 224-308-1

N(sup 1)-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide compound with 2,2'-iminodiethanol (1:1)

SULFISOXAZOLE DIOLAMINE

Sulfisoxazole diolamine (USAN)

N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)

Use of N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)

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