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N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)

更新时间:2024-09-13 19:45:48

N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)结构式
N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)结构式
品牌特惠专场
常用名 N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1) 英文名 N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)
CAS号 4299-60-9 分子量 372.44000
密度 N/A 沸点 482.2ºC at 760 mmHg
分子式 C15H24N4O5S 熔点 N/A
MSDS N/A 闪点 245.4ºC

 用途


硫异恶唑(磺胺呋喃唑)二乙醇胺是一种内皮素受体拮抗剂,对内皮素受体A和内皮素受体B的IC50值分别为0.60μM和22μM。硫异恶唑二乙醇胺是一种带有恶唑取代基的磺酰胺类抗菌剂。硫异恶唑二乙醇胺通过靶向内皮素受体A[1][2]抑制乳腺癌外泌体释放。

 名称

英文名 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide,2-(2-hydroxyethylamino)ethanol
英文别名 更多

 生物活性

描述 硫异恶唑(磺胺呋喃唑)二乙醇胺是一种内皮素受体拮抗剂,对内皮素受体A和内皮素受体B的IC50值分别为0.60μM和22μM。硫异恶唑二乙醇胺是一种带有恶唑取代基的磺酰胺类抗菌剂。硫异恶唑二乙醇胺通过靶向内皮素受体A[1][2]抑制乳腺癌外泌体释放。
相关类别
靶点

ETA:0.60 μM (IC50)

ETB:22 μM (IC50)

参考文献

[1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.

[2]. Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387.

 物理化学性质

沸点 482.2ºC at 760 mmHg
分子式 C15H24N4O5S
分子量 372.44000
闪点 245.4ºC
精确质量 372.14700
PSA 159.09000
LogP 2.36090

 英文别名

NU-445
N-(3,4-Dimethylisoxazol-5-yl)sulphanilamide,compound with 2,2'-iminodiethanol (1:1)
Sulfafurazol 2,2'-imidodiethanol
Benzenesulfonamide,4-amino-N-(3,4-dimethyl-5-isoxazolyl)-,compd. with 2,2'-iminobis(ethanol) (1:1)
EINECS 224-308-1
N(sup 1)-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide compound with 2,2'-iminodiethanol (1:1)
SULFISOXAZOLE DIOLAMINE
Sulfisoxazole diolamine (USAN)