N6-(2-Hydroxyethyl)adenosine

Modify Date: 2025-08-25 17:31:11

N6-(2-Hydroxyethyl)adenosine Structure
N6-(2-Hydroxyethyl)adenosine structure
 Common Name N6-(2-Hydroxyethyl)adenosine
CAS Number 4338-48-1 Molecular Weight 311.29
Density 1.88g/cm3 Boiling Point 725.8ºC at 760 mmHg
Molecular Formula C12H17N5O5 Melting Point 194-195ºC
MSDS N/A Flash Point 392.7ºC

 Use of N6-(2-Hydroxyethyl)adenosine


N6-(2-Hydroxyethyl)adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name (2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Synonym More Synonyms

 N6-(2-Hydroxyethyl)adenosine Biological Activity

Description N6-(2-Hydroxyethyl)adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.  

[2]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.88g/cm3
Boiling Point 725.8ºC at 760 mmHg
Melting Point 194-195ºC
Molecular Formula C12H17N5O5
Molecular Weight 311.29
Flash Point 392.7ºC
Exact Mass 311.12300
PSA 145.78000
Index of Refraction 1.806

 Safety Information

Hazard Codes Xi

 Synthetic Route

1-(2-hydroxyethyl)adenosine perchlorate structure

1-(2-hydroxyeth...

CAS#:96655-92-4

~94%

N6-(2-Hydroxyethyl)adenosine Structure

N6-(2-Hydroxyet...

CAS#:4338-48-1

Literature: Fujii, Tozo; Saito, Tohru; Terahara, Norihiko Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 3 p. 1094 - 1107
1-(2-hydroxyethyl)adenosine perchlorate structure

1-(2-hydroxyeth...

CAS#:96655-92-4

~50%

1-(2-hydroxyethyl)inosine structure

1-(2-hydroxyeth...

CAS#:33962-62-8

N6-(2-Hydroxyethyl)adenosine Structure

N6-(2-Hydroxyet...

CAS#:4338-48-1

Literature: Fujii, Tozo; Saito, Tohru; Terahara, Norihiko Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 3 p. 1094 - 1107

 Synonyms

(2R,3R,4S,5R)-2-[6-(2-hydroxyethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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