VES

Modify Date: 2025-08-20 12:18:54

VES structure	Common Name	VES
	CAS Number	4345-03-3	Molecular Weight	530.779
	Density	1.0±0.1 g/cm3	Boiling Point	625.8±55.0 °C at 760 mmHg
	Molecular Formula	C₃₃H₅₄O₅	Melting Point	~76 °C(lit.)
	MSDS	Chinese USA	Flash Point	187.0±25.0 °C

Use of VES

D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2].

Name	α-Tocopheryl Succinate
Synonym	More Synonyms

Description	D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells[1]. D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity[1]. D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells[2]. Cell Cytotoxicity Assay[1] Cell Line: HEI-OC1 cell line Concentration: 1-20 μM Incubation Time: 24 hours Result: Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM. Cell Viability Assay[1] Cell Line: HEI-OC1 cell line Concentration: 10 μM Incubation Time: 48 hours Result: Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis. Cell Cytotoxicity Assay[2] Cell Line: TC-1 tumor cells Concentration: 0, 25 and 50 μM Incubation Time: 18 hours Result: Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells.
In Vivo	D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor[2]. Animal Model: Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cells[2] Dosage: 1 and 2 mg/kg Administration: Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days Result: Dreased the tumor volume, especially with a dose of 2 mg/kg.
References	[1]. Kim SK, et al. The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Int J Pediatr Otorhinolaryngol. 2016 Jul;86:9-14. [2]. Kang TH, et al. Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects. PLoS One. 2014 Jul 29;9(7):e103562.

Density	1.0±0.1 g/cm3
Boiling Point	625.8±55.0 °C at 760 mmHg
Melting Point	~76 °C(lit.)
Molecular Formula	C₃₃H₅₄O₅
Molecular Weight	530.779
Flash Point	187.0±25.0 °C
Exact Mass	530.397095
PSA	72.83000
LogP	11.88
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.498
Storage condition	2-8°C

VES MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ9984000

CHEMICAL NAME :: Butanedioic acid, mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimet hyltridecyl)-2H-1- benzopyran-6-yl) ester, (2R-(2R*(4R*,8R*)))-

CAS REGISTRY NUMBER :: 4345-03-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C33-H54-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 25,273,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1129 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 934 (estimated) No. of Female Employees: 506 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	EJ9984000

Succinic anhydride

CAS#:108-30-5

DL-alpha-Tocopherol

CAS#:59-02-9

~84%

VES

CAS#:4345-03-3

Literature: Redoules, Daniel; Bordat, Pascal; Perie, Jean-Jacques Patent: US2004/236098 A1, 2004 ; Location in patent: Page 4 ;

Succinic acid

CAS#:110-15-6

DL-alpha-Tocopherol

CAS#:59-02-9

~72%

VES

CAS#:4345-03-3

Literature: Redoules, Daniel; Bordat, Pascal; Perie, Jean-Jacques Patent: US2004/236098 A1, 2004 ; Location in patent: Page 4 ;

(+)-Delta-Tocopherol

CAS#:119-13-1

VES

CAS#:4345-03-3

Literature: US2486539 , ;

β-Tocopherol

CAS#:16698-35-4

VES

CAS#:4345-03-3

Literature: US2486539 , ;

Precursor 5
CAS#:108-30-5 Succinic anhydride CAS#:59-02-9 DL-alpha-Tocopherol CAS#:110-15-6 Succinic acid CAS#:119-13-1 (+)-Delta-Tocopherol
CAS#:16698-35-4 β-Tocopherol
DownStream 0

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p66Shc longevity protein regulates the proliferation of human ovarian cancer cells.

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a-Tocopheryl Succinate

Butanedioic Acid (2R-(2R*(4R*,8R*)))-mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) Ester

a-Tocopheryl Acid Succinate

α-Tocopheryl acid succinate

(+)-α-Tocopheryl succinate

VES

EINECS 224-403-8

D-α-Tocopherol succinate

(+)-2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl Hydrogen Succinate

a-Tocopherol Acid Succinate

mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) butanedioate

Butanedioic acid Mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) Ester

d-alpha-Tocopherol succinate(E)

a-Tocopheryl Hydrogen Succinate

Butanedioic acid, mono[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl] ester

4-Oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl}oxy)butanoic acid

a-Tocopherol Hemisuccinate

Vitamin E Succinate

MFCD00072055

Covitol 1210

(+)-a-Tocopheryl Succinate

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: VES
Price: ￥108.0/100mg ￥178.0/250mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Vitamin E succinate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM - Vitamin E succinate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Synonyms

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