VES

Modify Date: 2024-01-02 16:25:14

VES Structure
VES structure
 Common Name VES
CAS Number 4345-03-3 Molecular Weight 530.779
Density 1.0±0.1 g/cm3 Boiling Point 625.8±55.0 °C at 760 mmHg
Molecular Formula C33H54O5 Melting Point ~76 °C(lit.)
MSDS Chinese USA Flash Point 187.0±25.0 °C

 Use of VES


D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2].

 Names

Name α-Tocopheryl Succinate
Synonym More Synonyms

 VES Biological Activity

Description D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2].
Related Catalog
In Vitro D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells[1]. D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity[1]. D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells[2]. Cell Cytotoxicity Assay[1] Cell Line: HEI-OC1 cell line Concentration: 1-20 μM Incubation Time: 24 hours Result: Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM. Cell Viability Assay[1] Cell Line: HEI-OC1 cell line Concentration: 10 μM Incubation Time: 48 hours Result: Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis. Cell Cytotoxicity Assay[2] Cell Line: TC-1 tumor cells Concentration: 0, 25 and 50 μM Incubation Time: 18 hours Result: Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells.
In Vivo D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor[2]. Animal Model: Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cells[2] Dosage: 1 and 2 mg/kg Administration: Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days Result: Dreased the tumor volume, especially with a dose of 2 mg/kg.
References

[1]. Kim SK, et al. The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Int J Pediatr Otorhinolaryngol. 2016 Jul;86:9-14.

[2]. Kang TH, et al. Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects. PLoS One. 2014 Jul 29;9(7):e103562.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 625.8±55.0 °C at 760 mmHg
Melting Point ~76 °C(lit.)
Molecular Formula C33H54O5
Molecular Weight 530.779
Flash Point 187.0±25.0 °C
Exact Mass 530.397095
PSA 72.83000
LogP 11.88
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.498
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EJ9984000
CHEMICAL NAME :
Butanedioic acid, mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimet hyltridecyl)-2H-1- benzopyran-6-yl) ester, (2R-(2R*(4R*,8R*)))-
CAS REGISTRY NUMBER :
4345-03-3
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C33-H54-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 25,273,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1129 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 934 (estimated) No. of Female Employees: 506 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS EJ9984000

 Synthetic Route

Succinic anhydride structure

Succinic anhydride

CAS#:108-30-5

DL-alpha-Tocopherol structure

DL-alpha-Tocopherol

CAS#:59-02-9

~84%

VES Structure

VES

CAS#:4345-03-3

Literature: Redoules, Daniel; Bordat, Pascal; Perie, Jean-Jacques Patent: US2004/236098 A1, 2004 ; Location in patent: Page 4 ;
Succinic acid structure

Succinic acid

CAS#:110-15-6

DL-alpha-Tocopherol structure

DL-alpha-Tocopherol

CAS#:59-02-9

~72%

VES Structure

VES

CAS#:4345-03-3

Literature: Redoules, Daniel; Bordat, Pascal; Perie, Jean-Jacques Patent: US2004/236098 A1, 2004 ; Location in patent: Page 4 ;
(+)-Delta-Tocopherol structure

(+)-Delta-Tocopherol

CAS#:119-13-1

~%

VES Structure

VES

CAS#:4345-03-3

Literature: US2486539 , ;
β-Tocopherol structure

β-Tocopherol

CAS#:16698-35-4

~%

VES Structure

VES

CAS#:4345-03-3

Literature: US2486539 , ;

 Articles14

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 Synonyms

a-Tocopheryl Succinate
Butanedioic Acid (2R-(2R*(4R*,8R*)))-mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) Ester
a-Tocopheryl Acid Succinate
α-Tocopheryl acid succinate
(+)-α-Tocopheryl succinate
VES
EINECS 224-403-8
D-α-Tocopherol succinate
(+)-2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl Hydrogen Succinate
a-Tocopherol Acid Succinate
mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) butanedioate
Butanedioic acid Mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) Ester
d-alpha-Tocopherol succinate(E)
a-Tocopheryl Hydrogen Succinate
Butanedioic acid, mono[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl] ester
4-Oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl}oxy)butanoic acid
a-Tocopherol Hemisuccinate
Vitamin E Succinate
MFCD00072055
Covitol 1210
(+)-a-Tocopheryl Succinate
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