(R)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID

Modify Date: 2024-01-06 13:44:23

(R)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID Structure
(R)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID structure
Common Name (R)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID
CAS Number 4350-07-6 Molecular Weight 220.22500
Density N/A Boiling Point N/A
Molecular Formula C11H12N2O3 Melting Point 27ºC
MSDS N/A Flash Point N/A

 Use of (R)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID


D-5-Hydroxytryptophan (D-5-HTP) is the D-isomers of 5-HTP, and can be isolated from DL-5-hydroxytryptophan by successive separations[1].

 Names

Name 5-hydroxy-D-tryptophan
Synonym More Synonyms

  Biological Activity

Description D-5-Hydroxytryptophan (D-5-HTP) is the D-isomers of 5-HTP, and can be isolated from DL-5-hydroxytryptophan by successive separations[1].
Related Catalog
References

[1]. J Arendt, et al. Alternative pathways of 5-hydroxyindole metabolism. II. The role transamination in the metabolism of D-5-hydroxytryptophan in the rat. Biochem Pharmacol. 1967 Mar;16(3):419-22.

 Chemical & Physical Properties

Melting Point 27ºC
Molecular Formula C11H12N2O3
Molecular Weight 220.22500
Exact Mass 220.08500
PSA 99.34000
LogP 1.52820

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YN7050000
CHEMICAL NAME :
Tryptophan, 5-hydroxy-, D-
CAS REGISTRY NUMBER :
4350-07-6
LAST UPDATED :
199109
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C11-H12-N2-O3
MOLECULAR WEIGHT :
220.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 69,523,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 69,523,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 69,523,1973

 Safety Information

Hazard Codes Xn,Xi
Risk Phrases 20/21-20/21/22-36/37/38-65
Safety Phrases 26-36
HS Code 2933990090

 Synthetic Route

~%

(R)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID Structure

(R)-2-AMINO-3-(...

CAS#:4350-07-6

Literature: Journal of Organic Chemistry, , vol. 22, p. 306,307

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

(2R)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
Tryptophan,5-hydroxy-,D
D-5-HTP (D-2-Amino-3-(5-hydroxyindolyl)propionic acid
C11H12N2O3
5-Hydroxytryptophan D-form
HRP
D-Tryptophan,5-hydroxy
D-5-Hydroxytryptophan