Genkwanin
Genkwanin structure
|
Common Name | Genkwanin | ||
|---|---|---|---|---|
| CAS Number | 437-64-9 | Molecular Weight | 284.263 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 546.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H12O5 | Melting Point | 290-292°C | |
| MSDS | Chinese USA | Flash Point | 209.7±23.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of GenkwaninGenkwanin is a major non-glycosylated flavonoid with anti-flammatory activities. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Genkwanin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities. |
|---|---|
| Related Catalog | |
| In Vitro | Cell viability analysis shows that Genkwanin does not affect the cell viability up to a concentration of 50 μM. Genkwanin inhibits the LPS-induced production of NO in a concentration-dependent manner. iNOS only expresses in the present of external stimulus. Genkwanin could not significantly affect the activity of iNOS. The effect of Genkwanin on the production of proinflammatory cytokines is examined. Genkwanin suppresses the productions of TNF-a, IL-1b and IL-6 in LPS stimulated RAW264.7 macrophages in a concentration-dependent manner. Genkwanin significantly suppresses the AP-1 signaling pathway but has little effect on the NF-kB signaling pathway. It is indicated that Genkwanin suppresses the phosphorylation of p38 and JNK in a concentration-dependent manner, but little affects ERK1/2 phosphorylation. Originally identified as an immediate early gene, MKP-1 is then found to be a dual specificity phosphatase acting as a negative regulator of ERK1/2, JNK and p38 MAPK activities, with predominant effects on the latter two. Pretreatment with Genkwanin markedly up-regulates the expression of MKP-1 without affecting MKP-1 mRNA[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 546.5±50.0 °C at 760 mmHg |
| Melting Point | 290-292°C |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.263 |
| Flash Point | 209.7±23.6 °C |
| Exact Mass | 284.068481 |
| PSA | 79.90000 |
| LogP | 2.36 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.669 |
| InChIKey | JPMYFOBNRRGFNO-UHFFFAOYSA-N |
| SMILES | COc1cc(O)c2c(=O)cc(-c3ccc(O)cc3)oc2c1 |
| Storage condition | Hygroscopic, -20?C Freezer, Under Inert Atmosphere |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Hazard Codes | Xn |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2914509090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Cytotoxicity against human A549 cells by SRB assay
Source: ChEMBL
Target: A549
External Id: CHEMBL4343917
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Name: The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre...
Source: 11924
Target: N/A
External Id: CGM data for Cell Systems paper Dec 2015
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Name: Inhibition of p56 lck
Source: ChEMBL
Target: Tyrosine-protein kinase Lck
External Id: CHEMBL941407
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Name: Inhibition of FabI at 100 uM
Source: ChEMBL
Target: Enoyl-acyl-carrier protein reductase
External Id: CHEMBL859175
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Name: Inhibition of FabG at 100 uM
Source: ChEMBL
Target: 3-oxoacyl-acyl-carrier protein reductase
External Id: CHEMBL859176
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Name: Inhibition of recombinant His-tagged human FLT3 (564 to 958 residues) expressed in ba...
Source: ChEMBL
Target: Receptor-type tyrosine-protein kinase FLT3
External Id: CHEMBL4814911
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|
Name: Inhibition of recombinant His-tagged human FLT3 (564 to 958 residues) expressed in ba...
Source: ChEMBL
Target: Receptor-type tyrosine-protein kinase FLT3
External Id: CHEMBL4814912
|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 5,4'-Dihydroxy-7-methoxyflavone |
| 5-hydroxy-4',7-dimethoxyflavone |
| MFCD00017452 |
| 7-Methoxyapigenin |
| Gengkwanin |
| 4',5-DIHYDROXY-7-METHOXYFLAVONE |
| 7-O-methyl-naringenin |
| 4′,5-Dihydroxy-7-methoxyflavone |
| 7-O-Methylapigenin |
| Apigenin 7-methyl ether |
| 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one |
| 5-Hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one |
| 5,14-dihydroxy-7-methoxyflavonone |
| Genkwanin |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of Genkwanin? |
| A: Polar surface area (PSA) of Genkwanin is 79.90000. |
| Q: What is the melting point of Genkwanin? |
| A: Melting point of Genkwanin is 290-292°C. |
| Q: What is the LogP of Genkwanin? |
| A: LogP of Genkwanin is 2.36. |
| Q: What is the safety information for Genkwanin? |
| A: Safety information for Genkwanin: S26-S36. |
| Q: What is the molecular weight of Genkwanin? |
| A: Molecular weight of Genkwanin is 284.263. |
| Q: What is the InChIKey of Genkwanin? |
| A: InChIKey of Genkwanin is JPMYFOBNRRGFNO-UHFFFAOYSA-N. |
| Q: What is the boiling point of Genkwanin? |
| A: Boiling point of Genkwanin is 546.5±50.0 °C at 760 mmHg. |
| Q: What is the CAS number of Genkwanin? |
| A: CAS number of Genkwanin is 437-64-9. |
| Q: What English synonyms does Genkwanin have? |
| A: English synonyms of Genkwanin: 5,4'-Dihydroxy-7-methoxyflavone, 5-hydroxy-4',7-dimethoxyflavone, MFCD00017452, 7-Methoxyapigenin, Gengkwanin, 4',5-DIHYDROXY-7-METHOXYFLAVONE, 7-O-methyl-naringenin, 4′,5-Dihydroxy-7-methoxyflavone, 7-O-Methylapigenin, Apigenin 7-methyl ether, 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one, 5-Hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one, 5,14-dihydroxy-7-methoxyflavonone, Genkwanin. |
| Q: What is the English name of Genkwanin? |
| A: The English name of Genkwanin is Genkwanin. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |
| Henan Tianfu Chemical Co., Ltd. |