Epipodophyllotoxin

Modify Date: 2026-08-29 20:12:42

Epipodophyllotoxin structure	Common Name	Epipodophyllotoxin
	CAS Number	4375-07-9	Molecular Weight	414.40500
	Density	1.37g/cm3	Boiling Point	597.9ºC at 760 mmHg
	Molecular Formula	C₂₂H₂₂O₈	Melting Point	160.3 °C
	MSDS	N/A	Flash Point	210.2ºC

Use of Epipodophyllotoxin

(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	(5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Magedov IV, et, al. Reengineered epipodophyllotoxin. Chem Commun (Camb). 2012 Oct 28; 48(84): 10416-8.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.37g/cm3
Boiling Point	597.9ºC at 760 mmHg
Melting Point	160.3 °C
Molecular Formula	C₂₂H₂₂O₈
Molecular Weight	414.40500
Flash Point	210.2ºC
Exact Mass	414.13100
PSA	92.68000
LogP	2.40920
Index of Refraction	1.605
InChIKey	YJGVMLPVUAXIQN-LGWHJFRWSA-N
SMILES	COc1cc(C2c3cc4c(cc3C(O)C3COC(=O)C23)OCO4)cc(OC)c1OC

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV2520000

CAS REGISTRY NUMBER :: 4375-07-9

BEILSTEIN REFERENCE NO. :: 0099162

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C22-H22-O8

MOLECULAR WEIGHT :: 414.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 135 mg/kg

SEX/DURATION :: female 25 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 20 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,512,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5374 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 214 (estimated) No. of Female Employees: 214 (estimated)

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 0
DownStream 4
CAS#:477-47-4 Picropodophyllotoxin CAS#:518-28-5 Podophyllotoxin CAS#:138456-91-4 (3aR,4S,9R,9aR)... CAS#:1180-35-4 Acetylepipodoph...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Non-cytotoxic IMS activity (ratio LcV/MLR) was determined
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL847246

Name: Cytotoxicity against human primary amnion cells assessed as morphological changes by ...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL999159

Name: Antiviral activity against HSV1 infected in human primary amnion cells assessed as in...
Source: ChEMBL
Target: Human alphaherpesvirus 1
External Id: CHEMBL999158

Name: Inhibition of chicken brain microtubule polymerization after 30 mins
Source: ChEMBL
Target: N/A
External Id: CHEMBL3231043

Name: Cytotoxicity against mouse P388 cells
Source: ChEMBL
Target: P388
External Id: CHEMBL1025843

Name: Growth inhibition of human HT-29 cells after 72 hrs by SRB assay
Source: ChEMBL
Target: HT-29
External Id: CHEMBL2166893

Name: In vitro cytotoxicity against the A-549 (human lung carcinoma) neoplastic cell line
Source: ChEMBL
Target: A549
External Id: CHEMBL619517

Name: Growth inhibition of human A549 cells after 72 hrs by SRB assay
Source: ChEMBL
Target: A549
External Id: CHEMBL2166892

Name: Tested for immunosuppressive activity in mouse using allogenic MLR method
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL735757

Name: In vitro cytotoxicity against the P-388 (from DBA/2 mouse) neoplastic cell line
Source: ChEMBL
Target: P388
External Id: CHEMBL758432

Total 18, Current Page 1 of 2

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Sunphenon EGC

Epipodophyllotoxin

EPIGALLOCATECHIN

Teacatechin II

epi

Galloepicatechin

epigallocatechol

Greenteacatechins

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the uses of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one?

A: Main uses of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one: (-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1].

Q: What is the molecular formula of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one?

A: Molecular formula of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one is C22H22O8.

Q: What is the melting point of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one?

A: Melting point of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one is 160.3 °C.

Q: What is the SMILES notation of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one?

A: SMILES notation of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one is COc1cc(C2c3cc4c(cc3C(O)C3COC(=O)C23)OCO4)cc(OC)c1OC.

Q: What is the InChIKey of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one?

A: InChIKey of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one is YJGVMLPVUAXIQN-LGWHJFRWSA-N.

Q: What English synonyms does (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one have?

A: English synonyms of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one: Sunphenon EGC, Epipodophyllotoxin, EPIGALLOCATECHIN, Teacatechin II, epi, Galloepicatechin, epigallocatechol, Greenteacatechins.

Q: What is the boiling point of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one?

A: Boiling point of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one is 597.9ºC at 760 mmHg.

Q: What is the CAS number of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one?

A: CAS number of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one is 4375-07-9.

Q: What is the polar surface area (PSA) of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one?

A: Polar surface area (PSA) of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one is 92.68000.

Q: What are the downstream products of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one?

A: Related downstream products(CAS) of (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one: 477-47-4;518-28-5;138456-91-4;1180-35-4.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

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Product Name: Epipodophyllotoxin
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

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