Timonacic

Modify Date: 2024-01-02 19:00:06

Timonacic Structure
Timonacic structure
 Common Name Timonacic
CAS Number 444-27-9 Molecular Weight 133.169
Density 1.4±0.1 g/cm3 Boiling Point 350.3±37.0 °C at 760 mmHg
Molecular Formula C4H7NO2S Melting Point 199 - 201ºC
MSDS N/A Flash Point 165.7±26.5 °C

 Use of Timonacic


Timonacic is used as an adjuvant in the treatment of acute and hepatic disorders. It has also been used for the treatment of some cases of cancer, through the induction of the reverse transformation.

 Names

Name thioproline
Synonym More Synonyms

 Timonacic Biological Activity

Description Timonacic is used as an adjuvant in the treatment of acute and hepatic disorders. It has also been used for the treatment of some cases of cancer, through the induction of the reverse transformation.
Related Catalog
References

[1]. Bakry RS, et al. Spectrophotometric investigation of the formed chelate between timonacic and palladium(II) and its analytical applications. J Pharm Biomed Anal. 1998 May;17(1):95-101.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 350.3±37.0 °C at 760 mmHg
Melting Point 199 - 201ºC
Molecular Formula C4H7NO2S
Molecular Weight 133.169
Flash Point 165.7±26.5 °C
Exact Mass 133.019745
PSA 74.63000
LogP -0.39
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.566
Storage condition 2-8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ5425000
CHEMICAL NAME :
4-Thiazolidinecarboxylic acid
CAS REGISTRY NUMBER :
444-27-9
LAST UPDATED :
199709
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C4-H7-N-O2-S
MOLECULAR WEIGHT :
133.18
WISWESSER LINE NOTATION :
T5M CSTJ EVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Kidney, Ureter, Bladder - renal function tests depressed
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,778,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
875 mg/kg
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,399,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
494 mg/kg
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,399,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GMITAB Gazzetta Medica Italiana. (Turin, Italy) V.95-142, 1936-83. Volume(issue)/page/year: 131,265,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,68,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
715 mg/kg/5D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,837,1980 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
30 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Endocrine - effect on menstrual cycle
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,453,1987

 Safety Information

RIDADR UN 2811
Packaging Group III
Hazard Class 6.1(b)
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

(4R)-1,3-Thiazolidine-4-carboxylic acid
L-4-Thiazolidinecarboxylic acid
L-Thioproline
(R)-(-)-4-Thiazolidinecarboxylic acid
L- thiazolidine-4-carboxylic acid
MFCD00128958
EINECS 207-146-6
(4R)-4-Thiazolidinecarboxylic acid
(R)-Thiazolidine-4-carboxylic acid
4-thiazolidinecarboxylic acid
1-thiazolidine-4-carboxylic acid
L-Thiazolidine-4-carboxylic acid
Thiazolidine-4-carboxylic acid
4-Thiazolidinecarboxylic acid, (4R)-
Timonacic
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