Lenalidomide-4-aminomethyl hydrochloride

Modify Date: 2024-01-13 08:43:24

Lenalidomide-4-aminomethyl hydrochloride Structure
Lenalidomide-4-aminomethyl hydrochloride structure
Common Name Lenalidomide-4-aminomethyl hydrochloride
CAS Number 444289-05-8 Molecular Weight 309.75
Density N/A Boiling Point N/A
Molecular Formula C14H16ClN3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lenalidomide-4-aminomethyl hydrochloride


Lenalidomide-4-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1]

 Names

Name Lenalidomide-4-aminomethyl hydrochloride
Synonym More Synonyms

 Lenalidomide-4-aminomethyl hydrochloride Biological Activity

Description Lenalidomide-4-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1]
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Molecular Formula C14H16ClN3O3
Molecular Weight 309.75

 Safety Information

Hazard Codes Xi

 Synonyms

MFCD32703223
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