Lenalidomide-4-aminomethyl

Modify Date: 2024-01-14 10:18:52

Lenalidomide-4-aminomethyl structure	Common Name	Lenalidomide-4-aminomethyl
	CAS Number	790652-68-5	Molecular Weight	273.29
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₅N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Lenalidomide-4-aminomethyl

Lenalidomide-4-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC[1].

Name	Lenalidomide-4-aminomethyl
Synonym	More Synonyms

Description	Lenalidomide-4-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Molecular Formula	C₁₄H₁₅N₃O₃
Molecular Weight	273.29

Hazard Codes	Xi

MFCD32201918

DC Chemicals Limited
China
Product Name: Lenalidomide-4-aminomethyl
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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