Methoxymethyldiphenylphosphine oxide

Modify Date: 2025-08-25 19:15:47

Methoxymethyldiphenylphosphine oxide Structure
Methoxymethyldiphenylphosphine oxide structure
Common Name Methoxymethyldiphenylphosphine oxide
CAS Number 4455-77-0 Molecular Weight 246.242
Density 1.1±0.1 g/cm3 Boiling Point 334.7±25.0 °C at 760 mmHg
Molecular Formula C14H15O2P Melting Point 115-117ºC
MSDS Chinese USA Flash Point 170.0±43.5 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name (Methoxymethyl)Diphenylphosphine Oxide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 334.7±25.0 °C at 760 mmHg
Melting Point 115-117ºC
Molecular Formula C14H15O2P
Molecular Weight 246.242
Flash Point 170.0±43.5 °C
Exact Mass 246.080963
PSA 36.11000
LogP 1.59
Appearance of Characters Crystalline Powder | White to pale yellow
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.556
Water Solubility methylene chloride: 0.1 g/mL, clear

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ0199360
CHEMICAL NAME :
Phosphine oxide, diphenyl(methoxymethyl)-
CAS REGISTRY NUMBER :
4455-77-0
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H15-O2-P
MOLECULAR WEIGHT :
246.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(4),22,1990

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
Risk Phrases R22
Safety Phrases S22-S36/37
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS SZ0199360
HS Code 2919900090

 Synthetic Route

~%

Methoxymethyldiphenylphosphine oxide Structure

Methoxymethyldi...

CAS#:4455-77-0

Literature: STRAITMARK HOLDING AG; BURCK, Sebastian, R., W.; NOTTÉ, Patrick Patent: WO2013/17564 A2, 2013 ; Location in patent: Page/Page column 48; 49 ;

~72%

Methoxymethyldiphenylphosphine oxide Structure

Methoxymethyldi...

CAS#:4455-77-0

Literature: Morita, Hiroyuki; Tashiro, Shintaro; Takeda, Masahiro; Fujimori, Ken; Yamada, Nobuhiko; Chanmiya Sheikh; Kawaguchi, Hiroyuki Tetrahedron, 2008 , vol. 64, # 16 p. 3589 - 3595

~%

Methoxymethyldiphenylphosphine oxide Structure

Methoxymethyldi...

CAS#:4455-77-0

Literature: STRAITMARK HOLDING AG; BURCK, Sebastian R., W.; COGELS, Samuel, Corentin; NOTTE, Patrick Patent: WO2012/98255 A1, 2012 ; Location in patent: Page/Page column 44 ;

~54%

Methoxymethyldiphenylphosphine oxide Structure

Methoxymethyldi...

CAS#:4455-77-0

Literature: Ngwendson, Julius N.; Schultze, Cassandra M.; Bollinger, Jordan W.; Banerjee, Anamitro Canadian Journal of Chemistry, 2008 , vol. 86, # 7 p. 668 - 675

~25%

Methoxymethyldiphenylphosphine oxide Structure

Methoxymethyldi...

CAS#:4455-77-0

Literature: Maleki, Mehran; Miller, Allen; Lever, O. William Jr. Tetrahedron Letters, 1981 , vol. 22, p. 365 - 368

~%

Methoxymethyldiphenylphosphine oxide Structure

Methoxymethyldi...

CAS#:4455-77-0

Literature: Aguiar,A.M. et al. Journal of Organic Chemistry, 1967 , vol. 32, p. 2383 - 2387

~%

Methoxymethyldiphenylphosphine oxide Structure

Methoxymethyldi...

CAS#:4455-77-0

Literature: Hellmann,H.; Bader,J. Tetrahedron Letters, 1961 , p. 724 - 729

~%

Methoxymethyldiphenylphosphine oxide Structure

Methoxymethyldi...

CAS#:4455-77-0

Literature: Earnshaw,C. et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 3099 - 3106 Full Text View citing articles Show Details Botteghi,C. et al. Synthetic Communications, 1976 , vol. 6, p. 549 - 554

~%

Methoxymethyldiphenylphosphine oxide Structure

Methoxymethyldi...

CAS#:4455-77-0

Literature: Earnshaw,C. et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 3099 - 3106

 Customs

HS Code 2919900090
Summary 2919900090 other phosphoric esters and their salts, including lactophosphates; their halogenated, sulphonated, nitrated or nitrosated derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

 Articles4

More Articles
C.E. Earnshaw et al.

J. Chem. Soc. Perkin Trans. I , 3099, (1979)

M. Bertrand et al.

J. Chem. Soc. Chem. Commun. , 529, (1979)

H. Magari et al.

Chem. Lett. , 1143, (1982)

 Synonyms

(Methoxymethyl)(diphenyl)phosphine oxide
MFCD00015451
(Methoxymethyl)(diphenyl)phosphan-oxid
Methoxymethyldiphenylphosphine oxide
EINECS 224-704-4
Phosphorane, (methoxymethyl)diphenyl-, oxide
[methoxymethyl(phenyl)phosphoryl]benzene
Diphenyl(methoxymethyl)phosphine Oxide
Methoxymethyl(diphenyl)phosphine Oxide
(Methoxymethyl)diphenylphosphine oxide
(Methoxymethyl)(diphenyl)phosphane oxide
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