2-Amino-5-fluorobenzoic acid
2-Amino-5-fluorobenzoic acid structure
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Common Name | 2-Amino-5-fluorobenzoic acid | ||
|---|---|---|---|---|
| CAS Number | 446-08-2 | Molecular Weight | 155.13 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 318.2±27.0 °C at 760 mmHg | |
| Molecular Formula | C7H6FNO2 | Melting Point | 181-183 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 146.2±23.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of 2-Amino-5-fluorobenzoic acid2-Amino-5-fluorobenzoic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 5-fluoroanthranilic acid |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 2-Amino-5-fluorobenzoic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
|---|---|
| Related Catalog | |
| In Vitro | 2-Amino-5-fluorobenzoic acid 是酵母中色氨酸通路的一种有毒抗代谢物，可用于反选择 TRP1，TRP1 是酿酒酵母中常用的遗传标记。由于此 trp1 菌株缺乏将蒽苯甲酸转化为色氨酸所需的酶，因此它对 2-amino-5-fluorobenzoic acid 反馈抑制具有抗性，从而能够对 TRP1 标记进行基于生长的阳性选择。2-氨基-5-氟苯甲酸经常用于涉及血浆操纵计算的遗传程序。 |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 318.2±27.0 °C at 760 mmHg |
| Melting Point | 181-183 °C(lit.) |
| Molecular Formula | C7H6FNO2 |
| Molecular Weight | 155.13 |
| Flash Point | 146.2±23.7 °C |
| Exact Mass | 155.038254 |
| PSA | 63.32000 |
| LogP | 1.64 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.606 |
| InChIKey | FPQMGQZTBWIHDN-UHFFFAOYSA-N |
| SMILES | Nc1ccc(F)cc1C(=O)O |
| Storage condition | Room temperature. |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2922499990 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~98%
2-Amino-5-fluor... CAS#:446-08-2 |
| Literature: AVANIR PHARMACEUTICALS Patent: WO2004/74218 A2, 2004 ; Location in patent: Page 106 ; |
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~93%
2-Amino-5-fluor... CAS#:446-08-2 |
| Literature: Karthikeyan; Jagadeesh, Rajenahally V.; Sree Sandhya; Puttaswamy; Nithya; Kumar, S. Senthil; Bhagat Applied Organometallic Chemistry, 2011 , vol. 25, # 1 p. 34 - 46 |
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~99%
2-Amino-5-fluor... CAS#:446-08-2 |
| Literature: Hoechst Aktiengesellschaft Patent: US5523472 A1, 1996 ; |
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~24%
2-Amino-5-fluor... CAS#:446-08-2 |
| Literature: Uchikawa, Osamu; Mitsui, Keita; Asakawa, Akiko; Morimoto, Shigeru; Yamamoto, Masataka; Kimura, Hiroyuki; Moriya, Takeo; Mizuno, Masahiro Patent: US2003/187014 A1, 2003 ; |
|
~%
2-Amino-5-fluor... CAS#:446-08-2 |
| Literature: Pokhodylo, Nazariy T.; Matiychuk, Vasyl S. Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 2 p. 415 - 420 |
|
~%
2-Amino-5-fluor... CAS#:446-08-2 |
| Literature: Holt; Sadler Proceedings of the Royal Society of London, Series B: Biological Sciences, 1958 , vol. 148, p. 481,488 |
|
~%
2-Amino-5-fluor... CAS#:446-08-2 |
| Literature: Rajsner; Metysova; Svatek; et al. Collection of Czechoslovak Chemical Communications, 1975 , vol. 40, # 3 p. 719 - 737 |
|
~%
2-Amino-5-fluor... CAS#:446-08-2 |
| Literature: Rajsner; Metysova; Svatek; et al. Collection of Czechoslovak Chemical Communications, 1975 , vol. 40, # 3 p. 719 - 737 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 8 | |
|---|---|
| DownStream 9 | |
CAS#:321-69-7
CAS#:319-24-4
CAS#:2343-25-1
CAS#:78755-80-3
CAS#:88145-90-8
CAS#:877264-44-3
CAS#:877264-43-2This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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The superoxide dismutases of Candida glabrata protect against oxidative damage and are required for lysine biosynthesis, DNA integrity and chronological life survival.
Microbiology 161 , 300-10, (2015) The fungal pathogen Candida glabrata has a well-defined oxidative stress response, is extremely resistant to oxidative stress and can survive inside phagocytic cells. In order to further our understan... |
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The Role of Amino Acid Permeases and Tryptophan Biosynthesis in Cryptococcus neoformans Survival.
PLoS ONE 10 , e0132369, (2015) Metabolic diversity is an important factor during microbial adaptation to different environments. Among metabolic processes, amino acid biosynthesis has been demonstrated to be relevant for survival f... |
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Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization.
J. Med. Chem. 33 , 1721, (1990) A novel series of 2-styrylquinazolin-4(3H-ones which inhibited tubulin polymerization and the growth of L1210 murine leukemia cells was discovered. Extensive structure-activity relationship studies su... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Binding affinity to Keap1 kelch domain (unknown origin) by surface plasmon resonance ...
Source: ChEMBL
Target: Kelch-like ECH-associated protein 1
External Id: CHEMBL5217617
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Name: Experimentally measured binding affinity data (Ki) for protein-ligand complexes deriv...
Source: Shanghai Institute of Organic Chemistry
Target: N/A
External Id: PDBbind-Ki for protein-ligand complexes
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 2-Amino-5-fluorobenzoic |
| 5-Fluoroanthranilic acid |
| AURORA KA-5382 |
| RARECHEM AL BO 2236 |
| ZR DF BVQ |
| EINECS 207-159-7 |
| 5-FAA |
| 5-Fluoroanthanilic acid |
| 5-fluoro-2-aminobenzoic acid |
| MFCD00055566 |
| 2-aMino-5-fluorobenzoic aicd |
| 2-amino-5-fluoro-benzoic acid |
| 4-fluoroanthranilic acid |
| 2-Amino-5-fluorobenzoic acid |
| 2-Amino-5-fluoro benzoicacid |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of 5-fluoroanthranilic acid? |
| A: CAS number of 5-fluoroanthranilic acid is 446-08-2. |
| Q: What are the uses of 5-fluoroanthranilic acid? |
| A: Main uses of 5-fluoroanthranilic acid: 2-Amino-5-fluorobenzoic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
| Q: What are the upstream materials of 5-fluoroanthranilic acid? |
| A: Related upstream materials(CAS) of 5-fluoroanthranilic acid: 320-98-9;399-52-0;394-28-5;446-33-3;443-69-6;351-09-7;49579-56-8;326-65-8. |
| Q: What are the downstream products of 5-fluoroanthranilic acid? |
| A: Related downstream products(CAS) of 5-fluoroanthranilic acid: 321-69-7;319-24-4;394-28-5;49579-56-8;2343-25-1;78755-80-3;88145-90-8;877264-44-3;877264-43-2. |
| Q: What is the polar surface area (PSA) of 5-fluoroanthranilic acid? |
| A: Polar surface area (PSA) of 5-fluoroanthranilic acid is 63.32000. |
| Q: What is the SMILES notation of 5-fluoroanthranilic acid? |
| A: SMILES notation of 5-fluoroanthranilic acid is Nc1ccc(F)cc1C(=O)O. |
| Q: What is the InChIKey of 5-fluoroanthranilic acid? |
| A: InChIKey of 5-fluoroanthranilic acid is FPQMGQZTBWIHDN-UHFFFAOYSA-N. |
| Q: What is the molecular formula of 5-fluoroanthranilic acid? |
| A: Molecular formula of 5-fluoroanthranilic acid is C7H6FNO2. |
| Q: What is the molecular weight of 5-fluoroanthranilic acid? |
| A: Molecular weight of 5-fluoroanthranilic acid is 155.13. |
| Q: What is the LogP of 5-fluoroanthranilic acid? |
| A: LogP of 5-fluoroanthranilic acid is 1.64. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |