1,3-difluoro-2-propanol

Modify Date: 2024-01-09 22:30:43

1,3-difluoro-2-propanol Structure
1,3-difluoro-2-propanol structure
Common Name 1,3-difluoro-2-propanol
CAS Number 453-13-4 Molecular Weight 96.07590
Density 1.24 g/mL at 25 °C(lit.) Boiling Point 54-55 °C34 mm Hg(lit.)
Molecular Formula C3H6F2O Melting Point N/A
MSDS Chinese USA Flash Point 108 °F
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Warning

 Names

Name 1,3-difluoro-2-propanol
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.24 g/mL at 25 °C(lit.)
Boiling Point 54-55 °C34 mm Hg(lit.)
Molecular Formula C3H6F2O
Molecular Weight 96.07590
Flash Point 108 °F
Exact Mass 96.03870
PSA 20.23000
LogP 0.28630
Vapour Pressure 68.5mmHg at 25°C
Index of Refraction n20/D 1.373(lit.)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UB1770000
CHEMICAL NAME :
2-Propanol, 1,3-difluoro-
CAS REGISTRY NUMBER :
453-13-4
BEILSTEIN REFERENCE NO. :
1732050
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C3-H6-F2-O
MOLECULAR WEIGHT :
96.09
WISWESSER LINE NOTATION :
F1YQ1F

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00467

 Safety Information

Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Warning
Hazard Statements H226-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi:Irritant;
Risk Phrases R10;R36/37/38
Safety Phrases S16-S26-S36
RIDADR UN 1987 3/PG 3
WGK Germany 3
RTECS UB1770000
Packaging Group III
Hazard Class 3
HS Code 2905590090

 Synthetic Route

~%

1,3-difluoro-2-propanol Structure

1,3-difluoro-2-...

CAS#:453-13-4

Literature: Cherbuliez,E. et al. Helvetica Chimica Acta, 1960 , vol. 43, p. 1135 - 1142

~%

1,3-difluoro-2-propanol Structure

1,3-difluoro-2-...

CAS#:453-13-4

Literature: Bergmann; Cohen Journal of the Chemical Society, 1958 , p. 2259,2260

 Customs

HS Code 2905590090
Summary 2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Articles3

More Articles
The mode of toxic action of the pesticide gliftor: the metabolism of 1,3-difluoroacetone to (-)-erythro-fluorocitrate.

J. Biochem. Mol. Toxicol. 15(1) , 47-54, (2001)

The biochemical toxicology of 1,3-difluoroacetone, a known metabolite of the major ingredient of the pesticide Gliftor (1,3-difluoro-2-propanol), was investigated in vivo and in vitro. Rat kidney homo...

Haloalcohols deplete glutathione when incubated with fortified liver fractions.

Xenobiotica 29(5) , 533-45, (1999)

1. This study has examined the ability of dichloropropanols, haloalcohols and their putative metabolites to deplete glutathione when incubated with liver fractions obtained from untreated and differen...

The biochemical toxicology of 1,3-difluoro-2-propanol, the major ingredient of the pesticide gliftor: the potential of 4-methylpyrazole as an antidote.

J. Biochem. Mol. Toxicol. 12(1) , 41-52, (1998)

Administration to rats of 1,3-difluoro-2-propanol (100 mg kg-1 body weight), the major ingredient of the pesticide gliftor, resulted in accumulation of citrate in the kidney after a 3 hour lag phase. ...

 Synonyms

EINECS 207-216-6
1,3-difluoropropan-2-ol
1,3-Difluoro-2-propanol
MFCD00000452