JAK3-IN-14

Modify Date: 2024-02-10 12:03:26

JAK3-IN-14 structure	Common Name	JAK3-IN-14
	CAS Number	454234-24-3	Molecular Weight	287.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₃N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JAK3-IN-14

JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively[1].

Name	5-pyridin-3-yl-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one

Description	JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK
Target	JAK3:38 nM (IC50) JAK2:600 nM (IC50)
References	[1]. Chen JJ, et al. Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5633-8.

Molecular Formula	C₁₈H₁₃N₃O
Molecular Weight	287.32
Exact Mass	287.10600
PSA	57.78000
LogP	3.70740

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: JAK3-IN-14
Price: Check
Purity: 98.98%
Delivery: 10 Day
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.