JAK3-IN-14
Modify Date: 2024-02-10 12:03:26
JAK3-IN-14 structure
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Common Name | JAK3-IN-14 | ||
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| CAS Number | 454234-24-3 | Molecular Weight | 287.32 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H13N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JAK3-IN-14JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively[1]. |
| Name | 5-pyridin-3-yl-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one |
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| Description | JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively[1]. |
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| Related Catalog | |
| Target |
JAK3:38 nM (IC50) JAK2:600 nM (IC50) |
| References |
| Molecular Formula | C18H13N3O |
|---|---|
| Molecular Weight | 287.32 |
| Exact Mass | 287.10600 |
| PSA | 57.78000 |
| LogP | 3.70740 |