Arylomycin A2

• 常用名: Arylomycin A2
• 英文名: Arylomycin A2
• CAS号: 459844-20-3
• 分子量: 824.96
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₂H₆₀N₆O₁₁
• 熔点: N/A
• 闪点: N/A

Arylomycin A2用途

芳洛霉素A2是一种抗生素,是一种脂肽I型信号肽酶(SPase I)抑制剂。芳洛霉素A2具有抗菌作用[1]。

Arylomycin A2名称

• 英文名: Arylomycin A2

Arylomycin A2生物活性

• 描述: 芳洛霉素A2是一种抗生素,是一种脂肽I型信号肽酶(SPase I)抑制剂。芳洛霉素A2具有抗菌作用[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 芳洛霉素A2对自由生活的表皮葡萄球菌细胞表现出非常有效的抗菌活性。阿瑞霉素A2对浮游表皮葡萄球菌1457和RP62A的MIC值分别为0.235μg/mL和0.058μg/mL。芳洛霉素A2对表皮葡萄球菌生物膜显示出抗菌作用,并显著减少生物膜的形成[2]。
• 参考文献:

  [1]. Mark Paetzel, et al. Crystallographic and biophysical analysis of a bacterial signal peptidase in complex with a lipopeptide-based inhibitor. J Biol Chem. 2004 Jul 16;279(29):30781-90.

  [2]. Katrijn Bockstael, et al. Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis. Microbiology (Reading). 2009 Nov;155(Pt 11):3719-3729.

Arylomycin A2物理化学性质

• 分子式: C₄₂H₆₀N₆O₁₁
• 分子量: 824.96

Arylomycin A2靶点实验

查看更多实验

实验名称：Antibacterial activity against Escherichia coli assessed as bacterial cell growth inh... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5216155

实验名称：Antibacterial activity against Staphylococcus epidermidis assessed as growth inhibiti... 来源：ChEMBL 靶标：Staphylococcus epidermidis External Id：CHEMBL3225362

实验名称：Antibacterial activity against Staphylococcus epidermidis assessed as bacterial cell ... 来源：ChEMBL 靶标：Staphylococcus epidermidis External Id：CHEMBL5216157

实验名称：Antibacterial activity against Staphylococcus aureus assessed as bacterial cell growt... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5216153

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate US... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1816116

共5条，当前第1页，共1页

1