Triethylene glycol monodecyl ether

Modify Date: 2024-01-16 13:06:31

Triethylene glycol monodecyl ether Structure
Triethylene glycol monodecyl ether structure
Common Name Triethylene glycol monodecyl ether
CAS Number 4669-23-2 Molecular Weight 290.43900
Density 0.936 g/mL at 20ºC(lit.) Boiling Point N/A
Molecular Formula C16H34O4 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of Triethylene glycol monodecyl ether


Triethylene glycol monodecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-(2-decoxyethoxy)ethoxy]ethanol
Synonym More Synonyms

 Triethylene glycol monodecyl ether Biological Activity

Description Triethylene glycol monodecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 0.936 g/mL at 20ºC(lit.)
Molecular Formula C16H34O4
Molecular Weight 290.43900
Exact Mass 290.24600
PSA 47.92000
LogP 3.16920
Index of Refraction n20/D 1.449
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

~84%

Triethylene glycol monodecyl ether Structure

Triethylene gly...

CAS#:4669-23-2

Literature: Dow Global Technologies LLC; TULCHINSKY, Michael, L.; BRIGGS, John, R.; RAND, Cynthia, L. Patent: EP2318346 B1, 2013 ; Location in patent: Paragraph 0077 ;

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Triethylene glycol monodecyl ether Structure

Triethylene gly...

CAS#:4669-23-2

Literature: Kim, Ki-Hyun; Kim, Jong-Uk; Cha, Sang-Ho; Lee, Jong-Chan Journal of the American Chemical Society, 2009 , vol. 131, p. 7482 - 7483

 Articles2

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The action of alcohols and other non-ionic surface active substances on the sodium current of the squid giant axon.

J. Physiol. 341 , 411, (1983)

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The effect of surfactants upon rat peritoneal mast cells in vitro.

Food Chem. Toxicol. 14 , 425, (1976)

 Synonyms

Decyltriglycol
Triethylene glycol monodecyl ether
triethylene glycol monodecyl ether
Emulgin BL 309
C10E3
3,6,9-trioxa-1-nonadecanol
n-decyl triethylene glycol monoether
Triethyleneglycol monodecyl ether solution
triethylene glycol mono-n-decyl ether
Decyl triethylene glycol ether
Triethyleneglycol monodecyl ether 1 mM solution
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