GW438014A

Modify Date: 2024-02-26 10:27:09

Use of GW438014A

GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents[1].

Name	N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide methanesulfonate (1:1)
Synonym	More Synonyms

Description	GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
In Vivo	GW438014A (10 mg/kg; i.p.; daily, for 7 d) 抑制大鼠和食物剥夺的遗传性肥胖 ob/ob 小鼠的自发和过夜禁食诱导和 NPY 诱导的摄食[1]。 Animal Model: obese ob/ob mice[1] Dosage: 10 mg/kg Administration: intraperitoneal injection; daily, for 7 d Result: Decreased the rate of weight gain in both lean and obese rats.
References	[1]. Daniels AJ, et, al. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul Pept. 2002 Jun 15;106(1-3):47-54.

Benzamide, N-[1-(2-phenylethyl)-1H-benzimidazol-2-yl]-, methanesulfonate (1:1)

N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide methanesulfonate (1:1)

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Price: ￥1000/5 mg

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