1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

Modify Date: 2024-01-02 19:14:42

1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane Structure
1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane structure
 Common Name 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane
CAS Number 470-67-7 Molecular Weight 154.249
Density 1.0±0.1 g/cm3 Boiling Point 173.5±8.0 °C at 760 mmHg
Molecular Formula C10H18O Melting Point −46 °C(lit.)
MSDS Chinese USA Flash Point 50.7±15.3 °C
Symbol GHS02
GHS02		 Signal Word Warning

 Use of 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane


1,4-Cineole is a widely distributed, natural, oxygenated monoterpene[1]. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1[2].

 Names

Name 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane
Synonym More Synonyms

  Biological Activity

Description 1,4-Cineole is a widely distributed, natural, oxygenated monoterpene[1]. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1[2].
Related Catalog
References

[1]. Rosazza JP, et al. Microbial hydroxylation of 1,4-cineole. Appl Environ Microbiol. 1987 Oct;53(10):2482-6.

[2]. Takaishi M, et al. 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain. 2012 Nov 29;8:86.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 173.5±8.0 °C at 760 mmHg
Melting Point −46 °C(lit.)
Molecular Formula C10H18O
Molecular Weight 154.249
Flash Point 50.7±15.3 °C
Exact Mass 154.135757
PSA 9.23000
LogP 2.58
Vapour Pressure 1.7±0.3 mmHg at 25°C
Index of Refraction 1.491
Storage condition -20℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OS9274000
CHEMICAL NAME :
p-Menthane, 1,4-epoxy-
CAS REGISTRY NUMBER :
470-67-7
BEILSTEIN REFERENCE NO. :
0104974
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H18-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,291,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,291,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2327 No. of Facilities: 2350 (estimated) No. of Industries: 29 No. of Occupations: 26 No. of Employees: 38044 (estimated) No. of Female Employees: 9165 (estimated)

 Safety Information

Symbol GHS02
GHS02
Signal Word Warning
Hazard Statements H226
Precautionary Statements P210-P403 + P235
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Risk Phrases R10
Safety Phrases S16
RIDADR UN 1993 3/PG 3
WGK Germany 2
RTECS OS9274000
Packaging Group III
Hazard Class 3.2

 Synthetic Route

 Articles10

More Articles
Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves.

Life Sci. 92(6-7) , 359-67, (2013)

Transient receptor potential (TRP) vanilloid-1 (TRPV1) and melastatin-8 (TRPM8) channels play a role in transmitting sensory information in primary-afferent neurons. TRPV1 agonists at high concentrati...

1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.

Mol. Pain 8 , 86, (2012)

Essential oils are often used in alternative medicine as analgesic and anti-inflammatory remedies. However, the specific compounds that confer the effects of essential oils and the molecular mechanism...

[Analysis of the chemical constituents of essential oil from Chimonanthus zhejiangensis by GC-MS].

Zhong Yao Cai 33(3) , 385-7, (2010)

To analyze the chemical constituents of the essential oil from Chimonanthus zhejiangensis.Steam distillation was employed to extract volatile compounds of essential oil from Chimonanthus zhejiangensis...

 Synonyms

1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane
Isocineole
1,4-Cineole (natural)
MFCD00209502
1-isopropyl-4-methyl-7-oxa-bicyclo[2.2.1]heptane
1-(2-methylethyl)-4-methyl-7-oxabicyclo[2.2.1]heptane
1,4-EPOXY-P-MENTHANE
1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane
7-Oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-
1,4-Cineol
1,4-Cineole
FEMA No. 3658
p-Menthane,1,4-epoxy
EINECS 207-428-9
p-Menthane, 1,4-epoxy
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Chemsrc provides CAS#:470-67-7 MSDS, density, melting point, boiling point, structure, etc. Its name is 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane>> amp version: 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

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