1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

Modify Date: 2026-06-30 13:03:37

1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane structure	Common Name	1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane
	CAS Number	470-67-7	Molecular Weight	154.249
	Density	1.0±0.1 g/cm3	Boiling Point	173.5±8.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₈O	Melting Point	−46 °C(lit.)
	MSDS	Chinese USA	Flash Point	50.7±15.3 °C
	Symbol	GHS02	Signal Word	Warning

Use of 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

1,4-Cineole is a widely distributed, natural, oxygenated monoterpene[1]. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1[2].

Summary: 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane, also known as 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane, has a CAS number of 470-67-7, with a molecular formula of C10H18O and a molecular weight of 154.249. It appears as a colorless liquid with a camphor-like aroma. The melting point is -46°C and the boiling point is 173.5±8.0°C. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	1,4-Cineole is a widely distributed, natural, oxygenated monoterpene[1]. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer Research Areas >> Inflammation/Immunology
References	[1]. Rosazza JP, et al. Microbial hydroxylation of 1,4-cineole. Appl Environ Microbiol. 1987 Oct;53(10):2482-6. [2]. Takaishi M, et al. 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain. 2012 Nov 29;8:86.

Description

1,4-Cineole is a widely distributed, natural, oxygenated monoterpene[1]. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1[2].

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

References

[1]. Rosazza JP, et al. Microbial hydroxylation of 1,4-cineole. Appl Environ Microbiol. 1987 Oct;53(10):2482-6.

[2]. Takaishi M, et al. 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain. 2012 Nov 29;8:86.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.0±0.1 g/cm3
Boiling Point	173.5±8.0 °C at 760 mmHg
Melting Point	−46 °C(lit.)
Molecular Formula	C₁₀H₁₈O
Molecular Weight	154.249
Flash Point	50.7±15.3 °C
Exact Mass	154.135757
PSA	9.23000
LogP	2.58
Vapour Pressure	1.7±0.3 mmHg at 25°C
Index of Refraction	1.491
InChIKey	RFFOTVCVTJUTAD-UHFFFAOYSA-N
SMILES	CC(C)C12CCC(C)(CC1)O2
Storage condition	-20℃

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS9274000

CHEMICAL NAME :: p-Menthane, 1,4-epoxy-

CAS REGISTRY NUMBER :: 470-67-7

BEILSTEIN REFERENCE NO. :: 0104974

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H18-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,291,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,291,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2327 No. of Facilities: 2350 (estimated) No. of Industries: 29 No. of Occupations: 26 No. of Employees: 38044 (estimated) No. of Female Employees: 9165 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS02
Signal Word	Warning
Hazard Statements	H226
Precautionary Statements	P210-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Risk Phrases	R10
Safety Phrases	S16
RIDADR	UN 1993 3/PG 3
WGK Germany	2
RTECS	OS9274000
Packaging Group	III
Hazard Class	3.2

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:99-86-5 alpha-Terpinene CAS#:470-82-6 Cineole CAS#:562-74-3 Terpinine-4-ol CAS#:512-85-6 Ascaridole
CAS#:78-79-5 isoprene CAS#:565-48-0 (Z)-terpin CAS#:7664-93-9 Sulfuric acid CAS#:98-55-5 Terpineol
CAS#:7664-38-2 Phosphoric acid
DownStream 1
CAS#:562-74-3 Terpinine-4-ol

This table lists relevant public references with title, journal and publication metadata for this compound.

Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves.

Life Sci. 92(6-7) , 359-67, (2013)

Transient receptor potential (TRP) vanilloid-1 (TRPV1) and melastatin-8 (TRPM8) channels play a role in transmitting sensory information in primary-afferent neurons. TRPV1 agonists at high concentrati...

1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.

Mol. Pain 8 , 86, (2012)

Essential oils are often used in alternative medicine as analgesic and anti-inflammatory remedies. However, the specific compounds that confer the effects of essential oils and the molecular mechanism...

[Analysis of the chemical constituents of essential oil from Chimonanthus zhejiangensis by GC-MS].

Zhong Yao Cai 33(3) , 385-7, (2010)

To analyze the chemical constituents of the essential oil from Chimonanthus zhejiangensis.Steam distillation was employed to extract volatile compounds of essential oil from Chimonanthus zhejiangensis...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Toxicity to Musca domestica (house fly) applied to pronotum assessed as compound leve...
Source: ChEMBL
Target: Musca domestica
External Id: CHEMBL3069896

Name: Displacement of [3H]TBOB binding to GABA receptor in Musca domestica (house fly) head...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit beta
External Id: CHEMBL3070306

Total 2, Current Page 1 of 1

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

Isocineole

1,4-Cineole (natural)

MFCD00209502

1-isopropyl-4-methyl-7-oxa-bicyclo[2.2.1]heptane

1-(2-methylethyl)-4-methyl-7-oxabicyclo[2.2.1]heptane

1,4-EPOXY-P-MENTHANE

1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane

1,4-Cineol

1,4-Cineole

FEMA No. 3658

p-Menthane,1,4-epoxy

EINECS 207-428-9

p-Menthane, 1,4-epoxy

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the upstream materials of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane?

A: Related upstream materials(CAS) of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane: 99-86-5;470-82-6;562-74-3;512-85-6;78-79-5;565-48-0;7664-93-9;98-55-5;7664-38-2.

Q: What is the boiling point of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane?

A: Boiling point of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane is 173.5±8.0 °C at 760 mmHg.

Q: What are the uses of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane?

A: Main uses of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane: 1,4-Cineole is a widely distributed, natural, oxygenated monoterpene[1]. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1[2].

Q: What is the CAS number of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane?

A: CAS number of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane is 470-67-7.

Q: What is the melting point of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane?

A: Melting point of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane is −46 °C(lit.).

Q: What are the downstream products of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane?

A: Related downstream products(CAS) of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane: 562-74-3.

Q: What is the safety information for 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane?

A: Safety information for 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane: S16.

Q: What is the LogP of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane?

A: LogP of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane is 2.58.

Q: What is the English name of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane?

A: The English name of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane is 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane.

Q: What is the molecular formula of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane?

A: Molecular formula of 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane is C10H18O.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane
Price: Check
Purity: 85.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,4-Cineole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 1,4-Cineole
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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