(3β,5α,6β)-Androstane-3,5,6-triol

Modify Date: 2024-01-17 18:16:25

(3β,5α,6β)-Androstane-3,5,6-triol Structure
(3β,5α,6β)-Androstane-3,5,6-triol structure
Common Name (3β,5α,6β)-Androstane-3,5,6-triol
CAS Number 4725-51-3 Molecular Weight 308.456
Density 1.2±0.1 g/cm3 Boiling Point 430.1±35.0 °C at 760 mmHg
Molecular Formula C19H32O3 Melting Point N/A
MSDS N/A Flash Point 193.1±20.5 °C

 Use of (3β,5α,6β)-Androstane-3,5,6-triol


5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo[1].

 Names

Name 5α-androst-3β,5,6β-triol
Synonym More Synonyms

 (3β,5α,6β)-Androstane-3,5,6-triol Biological Activity

Description 5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo[1].
Related Catalog
Target

AMPK[1]

References

[1]. Xue D, et al. TRIOL Inhibits Rapid Intracellular Acidification and Cerebral Ischemic Injury: The Role of Glutamate in Neuronal Metabolic Reprogramming. ACS Chem Neurosci. 2022 Jun 30.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 430.1±35.0 °C at 760 mmHg
Molecular Formula C19H32O3
Molecular Weight 308.456
Flash Point 193.1±20.5 °C
Exact Mass 308.235138
PSA 60.69000
LogP 3.88
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.580

 Synonyms

androstane-3β,5α,6β-triol
Androstane-3,5,6-triol, (3β,5α,6β)-
Androstan-3β,5α,6β-triol
5α-androstane-3β,5,6β-triol
(3β,5α,6β)-Androstane-3,5,6-triol
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