GPR
Modify Date: 2026-07-01 13:10:11
GPR structure
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Common Name | GPR | ||
|---|---|---|---|---|
| CAS Number | 47295-77-2 | Molecular Weight | 328.36700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H24N6O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GPRGPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD). |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD). |
|---|---|
| Related Catalog | |
| In Vitro | GPR (1-100 μM; 24 h, 48 h) prevented Aβ-mediated increase in lactate dehydrogenase (LDH) release[1]. GPR (50 μM; 24 h, 48 h) prevents Ah-mediated inhibition of neuronal MTT reduction[1]. GPR (50 μM; 3 days) prevents Aβ-mediated increase in p53-positive cells[1]. GPR (50 μM; 24 h) effectively prevented the Aβ-mediated activation of caspase-3[1]. Apoptosis Analysis[1] Cell Line: p53-positive cells Concentration: 50 μM Incubation Time: 3 days Result: Inhibited Ah-induced increase in numbers of p53-positive neurons. |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C13H24N6O4 |
|---|---|
| Molecular Weight | 328.36700 |
| Exact Mass | 328.18600 |
| PSA | 178.12000 |
| LogP | 0.43820 |
| InChIKey | JYPCXBJRLBHWME-IUCAKERBSA-N |
| SMILES | NCC(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)O |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Neuroprotective against IFNgamma/LPS stimulated THP1 condition medium-induced neuroto...
Source: ChEMBL
Target: SH-SY5Y
External Id: CHEMBL3757856
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Name: Neuroprotective against IFNgamma/LPS stimulated THP1 condition medium-induced neuroto...
Source: ChEMBL
Target: SH-SY5Y
External Id: CHEMBL3757855
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Name: Neuroprotective against IFNgamma/LPS stimulated THP1 condition medium-induced neuroto...
Source: ChEMBL
Target: SH-SY5Y
External Id: CHEMBL3757854
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|
Name: Metabolic stability in human plasma assessed as half life by HPLC analysis
Source: ChEMBL
Target: Plasma
External Id: CHEMBL3757848
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Name: Neuroprotective against IFNgamma/LPS stimulated THP1 condition medium-induced neuroto...
Source: ChEMBL
Target: SH-SY5Y
External Id: CHEMBL3757853
|
|
Name: Neuroprotective against IFNgamma/LPS stimulated THP1 condition medium-induced neuroto...
Source: ChEMBL
Target: SH-SY5Y
External Id: CHEMBL3757852
|
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Glycylprolylarginine |
| Gly-pro-arg |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the Chinese name of 47295-77-2? |
| A: Chinese name of 47295-77-2 is 47295-77-2. |
| Q: What are the uses of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid? |
| A: Main uses of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid: GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD). |
| Q: What is the molecular formula of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid? |
| A: Molecular formula of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid is C13H24N6O4. |
| Q: What is the InChIKey of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid? |
| A: InChIKey of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid is JYPCXBJRLBHWME-IUCAKERBSA-N. |
| Q: What is the English name of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid? |
| A: The English name of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid is (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid. |
| Q: What is the molecular weight of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid? |
| A: Molecular weight of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid is 328.36700. |
| Q: What is the LogP of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid? |
| A: LogP of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid is 0.43820. |
| Q: What English synonyms does (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid have? |
| A: English synonyms of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid: Glycylprolylarginine, Gly-pro-arg. |
| Q: What is the SMILES notation of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid? |
| A: SMILES notation of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid is NCC(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)O. |
| Q: What is the CAS number of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid? |
| A: CAS number of (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid is 47295-77-2. |