VU714 oxalate
Modify Date: 2024-02-27 20:29:57
VU714 oxalate structure
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Common Name | VU714 oxalate | ||
|---|---|---|---|---|
| CAS Number | 474625-52-0 | Molecular Weight | 456.919 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H25ClN2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VU714 oxalateA potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays; inhibits other Kir channels with a rank order potency of Kir4.1 (IC50=13 µM) > Kir1.1 (IC50=16 µM) > Kir6.2/SUR1 (IC50=30 µM) > Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 (IC50 > 30 µM). |
| Name | TCMDC-124594 |
|---|---|
| Synonym | More Synonyms |
| Description | A potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays; inhibits other Kir channels with a rank order potency of Kir4.1 (IC50=13 µM) > Kir1.1 (IC50=16 µM) > Kir6.2/SUR1 (IC50=30 µM) > Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 (IC50 > 30 µM). |
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| References | References 1. Kharade SV, et al. Mol Pharmacol. 2017 Sep;92(3):338-346. 2. Swale DR, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23. View Related Products by Target Potassium Channel |
| Molecular Formula | C24H25ClN2O5 |
|---|---|
| Molecular Weight | 456.919 |
| Exact Mass | 456.145203 |
| 7-[(4-Benzyl-1-piperidinyl)methyl]-5-chloro-8-quinolinol ethanedioate (1:1) |
| TCMDC-124594 |
| MFCD02081500 |
| 7-[(4-Benzylpiperidin-1-yl)methyl]-5-chloroquinolin-8-ol ethanedioate (1:1) |
| 8-Quinolinol, 5-chloro-7-[[4-(phenylmethyl)-1-piperidinyl]methyl]-, ethanedioate (1:1) (salt) |