474625-52-0

474625-52-0 structure

Name: VU714 oxalate
Chemical Name: TCMDC-124594
CAS Number: 474625-52-0
Molecular Formula: C₂₄H₂₅ClN₂O₅
Molecular Weight: 456.919
Create Date: 2020-01-11 23:13:01
Modify Date: 2024-02-27 20:29:57
A potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays; inhibits other Kir channels with a rank order potency of Kir4.1 (IC50=13 µM) > Kir1.1 (IC50=16 µM) > Kir6.2/SUR1 (IC50=30 µM) > Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 (IC50 > 30 µM).

Name	TCMDC-124594
Synonyms	7-[(4-Benzyl-1-piperidinyl)methyl]-5-chloro-8-quinolinol ethanedioate (1:1) TCMDC-124594 MFCD02081500 7-[(4-Benzylpiperidin-1-yl)methyl]-5-chloroquinolin-8-ol ethanedioate (1:1) 8-Quinolinol, 5-chloro-7-[[4-(phenylmethyl)-1-piperidinyl]methyl]-, ethanedioate (1:1) (salt)

Description	A potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays; inhibits other Kir channels with a rank order potency of Kir4.1 (IC50=13 µM) > Kir1.1 (IC50=16 µM) > Kir6.2/SUR1 (IC50=30 µM) > Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 (IC50 > 30 µM).
References	References 1. Kharade SV, et al. Mol Pharmacol. 2017 Sep;92(3):338-346. 2. Swale DR, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23. View Related Products by Target Potassium Channel