Liriodenine

Modify Date: 2026-07-03 19:25:12

Liriodenine structure	Common Name	Liriodenine
	CAS Number	475-75-2	Molecular Weight	275.258
	Density	1.5±0.1 g/cm3	Boiling Point	531.0±19.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₉NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	275.0±21.5 °C

Use of Liriodenine

Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9[2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	liriodenine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Liriodenine is against P-388, KB, HT-29, MCF-7, A549, ASK and Hek-293 cells with IC50 values of 9.60 μM, 11.02 μM, 10.62 μM, 9.20 μM and 8.07μM, respectively.
References	[1]. Natthinee Anantachoke, et al. Cytotoxic Compounds From the Leaves and Stems of the Endemic Thai Plant Mitrephora sirikitiae. Pharm Biol

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.5±0.1 g/cm3
Boiling Point	531.0±19.0 °C at 760 mmHg
Molecular Formula	C₁₇H₉NO₃
Molecular Weight	275.258
Flash Point	275.0±21.5 °C
Exact Mass	275.058258
PSA	48.42000
LogP	3.30
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.768
InChIKey	MUMCCPUVOAUBAN-UHFFFAOYSA-N
SMILES	O=C1c2ccccc2-c2c3c(cc4ccnc1c24)OCO3

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RB6036000

CHEMICAL NAME :: Noraporphin-7-one, 4,5,6,6a-tetradehydro-1,2-(methylenedioxy)-

CAS REGISTRY NUMBER :: 475-75-2

BEILSTEIN REFERENCE NO. :: 0273167

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H9-NO3

MOLECULAR WEIGHT :: 975.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHREEB Pharmaceutical Research. (Thieme Inc., 381 Park Ave. S, New York, NY 10016) No.1- 1984- Volume(issue)/page/year: 4,495,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHREEB Pharmaceutical Research. (Thieme Inc., 381 Park Ave. S, New York, NY 10016) No.1- 1984- Volume(issue)/page/year: 4,495,1987

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes	Xi

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 7
CAS#:103769-50-2 secoroemerine CAS#:2030-53-7 Aporeine CAS#:87489-85-8 (2-bromophenyl)... CAS#:7224-93-3 1,4-bis(2-triph...
CAS#:7241-00-1 (-)-anonaine CAS#:87489-86-9 1-(2'-bromo-α-h... CAS#:103769-52-4 N-carbethoxysec...
DownStream 0

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 h...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL5226936

Name: Displacement of [3H]SCH-23390 from rat dopamine D1 receptor
Source: ChEMBL
Target: D(1A) dopamine receptor
External Id: CHEMBL944160

Name: Displacement of [3H]raclopride from rat dopamine D2 receptor
Source: ChEMBL
Target: D(2) dopamine receptor
External Id: CHEMBL944161

Name: Displacement of [3H]DA from rat DAT
Source: ChEMBL
Target: Sodium-dependent dopamine transporter
External Id: CHEMBL944162

Name: Inhibition of Wnt signalling in human STF/293 cells assessed as decrease in c-myc lev...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3868893

Name: Inhibition of Wnt signalling in human STF/293 cells assessed as decrease in PPARdelta...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3868894

Name: Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO ...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL4812826

Name: Inhibition of Wnt signalling in human STF/293 cells assessed as decrease in beta-cate...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3868895

Name: Antifungal activity against Aspergillus niger after 3 days by broth microdilution met...
Source: ChEMBL
Target: Aspergillus niger
External Id: CHEMBL1114915

Name: Antifungal activity against Saccharomyces cerevisiae after 3 days by broth microdilut...
Source: ChEMBL
Target: Saccharomyces cerevisiae
External Id: CHEMBL1114914

Total 97, Current Page 1 of 10

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Spermatheridin

Oxoushinsunine

8H-[1,3]Benzodioxolo[6,5,4-de]benzo[g]quinolin-8-one

8H-1,3-Benzodioxolo[6,5,4-de]benzo[g]quinolin-8-one

8H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinolin-8-one (9CI)

8H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one

Liriodenine

Ushinsunine,oxo

Spermatheridine

Micheline B

Oxoushinsunin

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of liriodenine?

A: CAS number of liriodenine is 475-75-2.

Q: What is the InChIKey of liriodenine?

A: InChIKey of liriodenine is MUMCCPUVOAUBAN-UHFFFAOYSA-N.

Q: What is the molecular weight of liriodenine?

A: Molecular weight of liriodenine is 275.258.

Q: What is the SMILES notation of liriodenine?

A: SMILES notation of liriodenine is O=C1c2ccccc2-c2c3c(cc4ccnc1c24)OCO3.

Q: What are the upstream materials of liriodenine?

A: Related upstream materials(CAS) of liriodenine: 103769-50-2;2030-53-7;87489-85-8;7224-93-3;7241-00-1;87489-86-9;103769-52-4.

Q: What is the English name of liriodenine?

A: The English name of liriodenine is liriodenine.

Q: What is the boiling point of liriodenine?

A: Boiling point of liriodenine is 531.0±19.0 °C at 760 mmHg.

Q: What is the polar surface area (PSA) of liriodenine?

A: Polar surface area (PSA) of liriodenine is 48.42000.

Q: What are the uses of liriodenine?

A: Main uses of liriodenine: Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9[2].

Q: What is the molecular formula of liriodenine?

A: Molecular formula of liriodenine is C17H9NO3.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

BioBioPha

Dayang Chem (Hangzhou) Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Liriodenine
Price: Check
Purity: 95.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Liriodenine
Price: ￥4500.0/5mg
Purity: 97.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 8H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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