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475-75-2

475-75-2 structure
475-75-2 structure
  • Name: Liriodenine
  • Chemical Name: liriodenine
  • CAS Number: 475-75-2
  • Molecular Formula: C17H9NO3
  • Molecular Weight: 275.258
  • Catalog: Natural product Alkaloid
  • Create Date: 2018-09-19 16:53:54
  • Modify Date: 2025-08-22 12:19:22
  • Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9[2].
Name liriodenine
Synonyms Spermatheridin
Oxoushinsunine
8H-[1,3]Benzodioxolo[6,5,4-de]benzo[g]quinolin-8-one
8H-1,3-Benzodioxolo[6,5,4-de]benzo[g]quinolin-8-one
8H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinolin-8-one (9CI)
8H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one
Liriodenine
Ushinsunine,oxo
Spermatheridine
Micheline B
Oxoushinsunin
Description Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9[2].
Related Catalog
In Vitro Liriodenine is against P-388, KB, HT-29, MCF-7, A549, ASK and Hek-293 cells with IC50 values of 9.60 μM, 11.02 μM, 10.62 μM, 9.20 μM and 8.07μM, respectively.
References

[1]. Natthinee Anantachoke, et al. Cytotoxic Compounds From the Leaves and Stems of the Endemic Thai Plant Mitrephora sirikitiae. Pharm Biol
Density 1.5±0.1 g/cm3
Boiling Point 531.0±19.0 °C at 760 mmHg
Molecular Formula C17H9NO3
Molecular Weight 275.258
Flash Point 275.0±21.5 °C
Exact Mass 275.058258
PSA 48.42000
LogP 3.30
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.768

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RB6036000
CHEMICAL NAME :
Noraporphin-7-one, 4,5,6,6a-tetradehydro-1,2-(methylenedioxy)-
CAS REGISTRY NUMBER :
475-75-2
BEILSTEIN REFERENCE NO. :
0273167
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C17-H9-NO3
MOLECULAR WEIGHT :
975.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHREEB Pharmaceutical Research. (Thieme Inc., 381 Park Ave. S, New York, NY 10016) No.1- 1984- Volume(issue)/page/year: 4,495,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHREEB Pharmaceutical Research. (Thieme Inc., 381 Park Ave. S, New York, NY 10016) No.1- 1984- Volume(issue)/page/year: 4,495,1987
Hazard Codes Xi
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