Isotetrandrine

Modify Date: 2024-01-02 20:49:38

Isotetrandrine Structure
Isotetrandrine structure
 Common Name Isotetrandrine
CAS Number 477-57-6 Molecular Weight 622.750
Density 1.2±0.1 g/cm3 Boiling Point 710.5±60.0 °C at 760 mmHg
Molecular Formula C38H42N2O6 Melting Point 180-182ºC
MSDS N/A Flash Point 175.8±30.1 °C

 Use of Isotetrandrine


Isotetrandrine is a bioactive component in S. acutum[1].

 Names

Name Isosinomenin A
Synonym More Synonyms

 Isotetrandrine Biological Activity

Description Isotetrandrine is a bioactive component in S. acutum[1].
Related Catalog
In Vitro Fangchi, derived from the rhizoma of S. acutum and the radix of S. tetrandra and S. acutum, has been widely used for the treatment of rheumatic arthritis[1].
References

[1]. Kim, Ji Hee et al. UHPLC Separation of Structurally Diverse Markers in Fangchi Species. (2013).

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 710.5±60.0 °C at 760 mmHg
Melting Point 180-182ºC
Molecular Formula C38H42N2O6
Molecular Weight 622.750
Flash Point 175.8±30.1 °C
Exact Mass 622.304260
PSA 61.86000
LogP 3.55
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.586

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NX7285000
CHEMICAL NAME :
1-Isotetrandrine
CAS REGISTRY NUMBER :
477-57-6
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C38-H42-N2-O6
MOLECULAR WEIGHT :
622.82

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65(5),176S,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2413,1976

 Safety Information

Hazard Codes Xi

 Synthetic Route

N-Methylcoclaurine structure

N-Methylcoclaurine

CAS#:1472-62-4

~%

Isotetrandrine Structure

Isotetrandrine

CAS#:477-57-6

Literature: Bhakuni; Singh; Jain Tetrahedron, 1980 , vol. 36, # 14 p. 2149 - 2151
(+/-)-1-(4-hydroxybenzyl)-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride structure

(+/-)-1-(4-hydr...

CAS#:17934-80-4

~%

Isotetrandrine Structure

Isotetrandrine

CAS#:477-57-6

Literature: Bhakuni; Singh; Jain Tetrahedron, 1980 , vol. 36, # 14 p. 2149 - 2151
didehydro-N-methylcoclaurinium iodide structure

didehydro-N-met...

CAS#:66277-16-5

~%

Isotetrandrine Structure

Isotetrandrine

CAS#:477-57-6

Literature: Bhakuni; Singh; Jain Tetrahedron, 1980 , vol. 36, # 14 p. 2149 - 2151
diazomethane structure

diazomethane

CAS#:186581-53-3

(1ξ,1'ξ)-6,6',12-Trimethoxy-2,2'-dimethylberbaman-7-ol structure

(1ξ,1'ξ)-6,6',1...

CAS#:38769-07-2

~%

Isotetrandrine Structure

Isotetrandrine

CAS#:477-57-6

Literature: Kupchan; Liepa; Baxter; Hintz Journal of Organic Chemistry, 1973 , vol. 38, # 10 p. 1846 - 1852
diazomethane structure

diazomethane

CAS#:186581-53-3

~%

Isotetrandrine Structure

Isotetrandrine

CAS#:477-57-6

Literature: Kugo Yakugaku Zasshi, 1959 , vol. 79, p. 322 Chem.Abstr., 1959 , p. 17161
diazomethane structure

diazomethane

CAS#:186581-53-3

Fangchinoline structure

Fangchinoline

CAS#:436-77-1

~%

Isotetrandrine Structure

Isotetrandrine

CAS#:477-57-6

Literature: Mitscher,L.A. et al. Journal of the Chemical Society [Section] D: Chemical Communications, 1971 , p. 589 - 590

 Synonyms

O,O'-Dimethylobamegine
isotetrandine
O-Methylberbamine
O,O'-Dimethylstepholine
6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman
Isosinomenine A
6,7,12,6'-tetramethoxy-2,2'-dimethyl-berbamane
1R,1'S isotetrandrine
1-isotetrandrine
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