Neostenine

Modify Date: 2024-01-02 01:50:32

Neostenine Structure
Neostenine structure
Common Name Neostenine
CAS Number 477953-07-4 Molecular Weight 277.40
Density 1.1±0.1 g/cm3 Boiling Point 414.6±45.0 °C at 760 mmHg
Molecular Formula C17H27NO2 Melting Point N/A
MSDS N/A Flash Point 146.3±19.6 °C

 Use of Neostenine


Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application[1][2].

 Names

Name (7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyldodecahydroazepi no[3,2,1-hi]furo[3,2-e]indol-10(2H)-one
Synonym More Synonyms

 Neostenine Biological Activity

Description Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application[1][2].
Related Catalog
References

[1]. Chung HS, et al. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med. 2003 Oct;69(10):914-20.  

[2]. Leung PH, et al. Intestinal absorption of Stemona alkaloids in a Caco-2 cell model. Planta Med. 2006 Feb;72(3):211-6.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 414.6±45.0 °C at 760 mmHg
Molecular Formula C17H27NO2
Molecular Weight 277.40
Flash Point 146.3±19.6 °C
Exact Mass 277.204193
PSA 29.54000
LogP 2.91
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.544

 Safety Information

Hazard Codes Xi

 Synonyms

Azepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one, 8-ethyldodecahydro-11-methyl-, (7aR,8R,8aR,11S,11aR,11bS,11cR)-
(7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyldodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one
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