477953-07-4

477953-07-4 structure

Name: Neostenine
Chemical Name: (7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyldodecahydroazepi no[3,2,1-hi]furo[3,2-e]indol-10(2H)-one
CAS Number: 477953-07-4
Molecular Formula: C₁₇H₂₇NO₂
Molecular Weight: 277.40
Catalog: Natural product Alkaloid
Create Date: 2018-06-26 12:14:01
Modify Date: 2024-01-02 01:50:32
Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application[1][2].

Name	(7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyldodecahydroazepi no[3,2,1-hi]furo[3,2-e]indol-10(2H)-one
Synonyms	Azepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one, 8-ethyldodecahydro-11-methyl-, (7aR,8R,8aR,11S,11aR,11bS,11cR)- (7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyldodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one

Description	Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein
References	[1]. Chung HS, et al. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med. 2003 Oct;69(10):914-20. [2]. Leung PH, et al. Intestinal absorption of Stemona alkaloids in a Caco-2 cell model. Planta Med. 2006 Feb;72(3):211-6.

Hazard Codes	Xi