CP-809101 structure
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Common Name | CP-809101 | ||
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CAS Number | 479683-64-2 | Molecular Weight | 304.77 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 486.6±45.0 °C at 760 mmHg | |
Molecular Formula | C15H17ClN4O | Melting Point | N/A | |
MSDS | N/A | Flash Point | 248.1±28.7 °C |
Use of CP-809101CP-809101 is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively. IC50 Value: 9.96(pEC50 for 5-HT2C); 7.19(pEC50 for 5-HT2B); 6.81(pEC50 for 5-HT2A)Target: 5-HT2C ReceptorCP-809101 is a potent, functionally selective 5-HT2C agonist that displays approximately 100% efficacy in vitro. The aim of the present studies was to assess the efficacy of a selective 5-HT2C agonist in animal models predictive of antipsychotic-like efficacy and side-effect liability. Similar to currently available antipsychotic drugs, CP-809101 dose-dependently inhibited conditioned avoidance responding (CAR, ED50 = 4.8 mg/kg, sc). CP-809101 antagonized both PCP- and d-amphetamine-induced hyperactivity with ED50 values of 2.4 and 2.9 mg/kg (sc), respectively and also reversed an apomorphine induced-deficit in prepulse inhibition. At doses up to 56 mg/kg, CP-809101 did not produce catalepsy. Thus, the present results demonstrate that the 5-HT2C agonist, CP-809101, has a pharmacological profile similar to that of the atypical antipsychotics with low extrapyramidal symptom liability. CP-809101 was inactive in two animal models of antidepressant-like activity, the forced swim test and learned helplessness. |
Name | 2-[(3-chlorophenyl)methoxy]-6-piperazin-1-ylpyrazine |
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Synonym | More Synonyms |
Description | CP-809101 is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively. IC50 Value: 9.96(pEC50 for 5-HT2C); 7.19(pEC50 for 5-HT2B); 6.81(pEC50 for 5-HT2A)Target: 5-HT2C ReceptorCP-809101 is a potent, functionally selective 5-HT2C agonist that displays approximately 100% efficacy in vitro. The aim of the present studies was to assess the efficacy of a selective 5-HT2C agonist in animal models predictive of antipsychotic-like efficacy and side-effect liability. Similar to currently available antipsychotic drugs, CP-809101 dose-dependently inhibited conditioned avoidance responding (CAR, ED50 = 4.8 mg/kg, sc). CP-809101 antagonized both PCP- and d-amphetamine-induced hyperactivity with ED50 values of 2.4 and 2.9 mg/kg (sc), respectively and also reversed an apomorphine induced-deficit in prepulse inhibition. At doses up to 56 mg/kg, CP-809101 did not produce catalepsy. Thus, the present results demonstrate that the 5-HT2C agonist, CP-809101, has a pharmacological profile similar to that of the atypical antipsychotics with low extrapyramidal symptom liability. CP-809101 was inactive in two animal models of antidepressant-like activity, the forced swim test and learned helplessness. |
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Related Catalog | |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 486.6±45.0 °C at 760 mmHg |
Molecular Formula | C15H17ClN4O |
Molecular Weight | 304.77 |
Flash Point | 248.1±28.7 °C |
PSA | 50.28000 |
LogP | 3.02 |
Vapour Pressure | 0.0±1.2 mmHg at 25°C |
Index of Refraction | 1.597 |
Storage condition | 2-8℃ |
2-[(3-Chlorobenzyl)oxy]-6-(1-piperazinyl)pyrazine |
cs-1201 |
CP-809,101 |
Pyrazine, 2-[(3-chlorophenyl)methoxy]-6-(1-piperazinyl)- |
CP-809101 |