Integerrimine

Modify Date: 2025-08-22 20:09:14

Integerrimine structure	Common Name	Integerrimine
	CAS Number	480-79-5	Molecular Weight	335.39500
	Density	1.25g/cm3	Boiling Point	563.7ºC at 760 mmHg
	Molecular Formula	C₁₈H₂₅NO₅	Melting Point	172 °C
	MSDS	N/A	Flash Point	294.7ºC

Use of Integerrimine

(-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila[1][2].

Name	Pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl(1,6)dioxacyclododecino(2,3,4-gh)
Synonym	More Synonyms

Description	(-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	(-)-Integerrimine (0.00625-0.05 mM) also must have mutagenic activity in somatic cells of Drosophila. (-)-Integerrimine in general requires cytochrome P450-dependent metabolic activation to exhibit genotoxic activity[1].
References	[1]. V R Campesato, et al. Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. Environ Mol Mutagen. 1997;29(1):91-7. [2]. Walber Toma, et al. Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers. Can J Physiol Pharmacol. 2004 May;82(5):319-25.

Density	1.25g/cm3
Boiling Point	563.7ºC at 760 mmHg
Melting Point	172 °C
Molecular Formula	C₁₈H₂₅NO₅
Molecular Weight	335.39500
Flash Point	294.7ºC
Exact Mass	335.17300
PSA	76.07000
LogP	1.13070
Vapour Pressure	4.68E-15mmHg at 25°C
Index of Refraction	1.57
InChIKey	HKODIGSRFALUTA-IKZAEVNJSA-N
SMILES	CC=C1CC(C)C(C)(O)C(=O)OCC2=CCN3CCC(OC1=O)C23

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM9080000

CHEMICAL NAME :: Integerrimine

CAS REGISTRY NUMBER :: 480-79-5

LAST UPDATED :: 199603

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H25-N-O5

MOLECULAR WEIGHT :: 335.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg/20D-I

TOXIC EFFECTS :: Related to Chronic Data - death

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 18750 ug/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,297,1990

Hazard Codes	Xi
RIDADR	UN 1544
Packaging Group	III
Hazard Class	6.1(b)

Name: Toxicity against Cricetulus griseus CHO (Chinese hamster ovary) cell by MTT assay
Source: ChEMBL
Target: CHO
External Id: CHEMBL3054995

Name: Toxicity against Spodoptera frugiperda (fall armyworm) Sf9 cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL3054470

Name: Antifeedant activity against Spodoptera littoralis L6 larvae assessed as biomass gain...
Source: ChEMBL
Target: Spodoptera littoralis
External Id: CHEMBL3054471

Name: Antifeedant activity against Spodoptera littoralis L6 larvae assessed as food consump...
Source: ChEMBL
Target: Spodoptera littoralis
External Id: CHEMBL3054472

Name: Antifeedant activity against Rhopalosiphum padi adults fed on compound treated Hordeu...
Source: ChEMBL
Target: Rhopalosiphum padi
External Id: CHEMBL3054473

Name: Antifeedant activity against Myzus persicae (green peach aphid) adults fed on compoun...
Source: ChEMBL
Target: Myzus persicae
External Id: CHEMBL3054474

Name: Antifeedant activity against Leptinotarsa decemlineata adults fed on compound treated...
Source: ChEMBL
Target: Leptinotarsa decemlineata
External Id: CHEMBL3054475

Name: Antifeedant activity against Spodoptera littoralis sixth-instar larvae fed on compoun...
Source: ChEMBL
Target: Spodoptera littoralis
External Id: CHEMBL3054476

Name: Phytotoxicity against Lactuca sativa var. Carrascoy (lettuce) assessed as inhibition ...
Source: ChEMBL
Target: Lactuca sativa
External Id: CHEMBL3054990

Name: Cytotoxicity against human A204 cells after 24 hrs by soft agar colony forming assay
Source: ChEMBL
Target: A204
External Id: CHEMBL1019134

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Intergerrimine

senecionyne

Squalidine

INTEGERRIMINE

seneciionine

12-hydroxy-senecionane-11,16-dione

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Integerrimine
Price: Check
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: INTEGERRIMINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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naturewill
China
Product Name: Integerrimine
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

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Integerrimine

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Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

IntegerrimineBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.