Alpha-Santonin

Modify Date: 2024-01-03 11:57:43

Alpha-Santonin structure	Common Name	Alpha-Santonin
	CAS Number	481-06-1	Molecular Weight	246.30200
	Density	1.18g/cm3	Boiling Point	423.4ºC at 760mmHg
	Molecular Formula	C₁₅H₁₈O₃	Melting Point	172-173 °C(lit.)
	MSDS	Chinese USA	Flash Point	189.7ºC
	Symbol	GHS06	Signal Word	Danger

Use of Alpha-Santonin

Santonin is an active principle of the plant Artemisia cina, which is formely used to treat worms[1].

Name	α-santonin
Synonym	More Synonyms

Description	Santonin is an active principle of the plant Artemisia cina, which is formely used to treat worms[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Sakipova Z, et al. Quantification of santonin in eight species of Artemisia from Kazakhstan by means of HPLC-UV: Method development and validation. PLoS One. 2017 Mar 16;12(3):e0173714.

Density	1.18g/cm3
Boiling Point	423.4ºC at 760mmHg
Melting Point	172-173 °C(lit.)
Molecular Formula	C₁₅H₁₈O₃
Molecular Weight	246.30200
Flash Point	189.7ºC
Exact Mass	246.12600
PSA	43.37000
LogP	2.41960
Vapour Pressure	2.24E-07mmHg at 25°C
Index of Refraction	-172.5 ° (C=2, CHCl3)
Storage condition	2-8°C

Alpha-Santonin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LE3150000

CHEMICAL NAME :: Eudesma-1,4-dien-12-oic acid, 6-alpha-hydroxy-3-oxo-, gamma-lactone, (11S)-

CAS REGISTRY NUMBER :: 481-06-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H18-O3

MOLECULAR WEIGHT :: 246.33

WISWESSER LINE NOTATION :: T B566 COV LV IHTT&J E1 I1 M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,301,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 52,79S,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02213 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4536 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 7 (estimated)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H302-H310-H315-H319-H330-H335
Precautionary Statements	P260-P280-P284-P302 + P350-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	2811
WGK Germany	3
RTECS	LE3150000
Packaging Group	II
Hazard Class	6.1(a)

Precursor 0
DownStream 7
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The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands.

J. Neurosci. 33(1) , 201-13, (2013)

Bitter taste is a basic taste modality, required to safeguard animals against consuming toxic substances. Bitter compounds are recognized by G-protein-coupled bitter taste receptors (TAS2Rs). The huma...

Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones.

Pharmacol. Biochem. Behav. 89(2) , 160-70, (2008)

Here we report the prevention and reversal of cocaine-induced behaviors in planarian worms by parthenolide and two related cyclic sesquiterpene lactones (SL), costunolide and santonin. Using establish...

Diminutive effect on T and B-cell proliferation of non-cytotoxic α-santonin derived 1,2,3-triazoles: a report.

Eur. J. Med. Chem. 60 , 365-75, (2013)

α-Santonin derived new series of 1,2,3-triazoles synthesized through Azide-Alkyne Huisgen 1,3-dipolar cycloaddition reaction between substituted aryl azide and a propargylated α-desmotrosantonin were ...

Semenen

EINECS 207-560-7

l-Santonin

A-SANTONIN

(3S,3aS,5aS,9bS)-3a,5,5a,9b-tetrahydro-3,5a,9-trimethylnaphtho[1,2-b]furan-2,8(3H,4H)-dione

MFCD00135865

alpha-santonin

(3S,3aS,5aS,9bS)-3,5a,9-trimethyl-3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione

SANTONIN

SANTONIN,A

(3S,5aS,9bS)-3a,5,5a,9b-Tetrahydro-3,5a,9-trimethylnaphtho[1,2-b]furan-2,8(3H,4H)dione

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Alpha-Santonin
Price: ￥318.0/5g ￥148.0/100mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Santonin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: SANTONIN
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Alpha-Santonin suppliers

Price: ￥550/10 mM * 1 mL in DMSO

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Alpha-Santonin

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Alpha-Santonin Biological Activity

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