Alpha-Santonin

Modify Date: 2024-01-03 11:57:43

Alpha-Santonin Structure
Alpha-Santonin structure
 Common Name Alpha-Santonin
CAS Number 481-06-1 Molecular Weight 246.30200
Density 1.18g/cm3 Boiling Point 423.4ºC at 760mmHg
Molecular Formula C15H18O3 Melting Point 172-173 °C(lit.)
MSDS Chinese USA Flash Point 189.7ºC
Symbol GHS06
GHS06		 Signal Word Danger

 Use of Alpha-Santonin


Santonin is an active principle of the plant Artemisia cina, which is formely used to treat worms[1].

 Names

Name α-santonin
Synonym More Synonyms

 Alpha-Santonin Biological Activity

Description Santonin is an active principle of the plant Artemisia cina, which is formely used to treat worms[1].
Related Catalog
References

[1]. Sakipova Z, et al. Quantification of santonin in eight species of Artemisia from Kazakhstan by means of HPLC-UV: Method development and validation. PLoS One. 2017 Mar 16;12(3):e0173714.

 Chemical & Physical Properties

Density 1.18g/cm3
Boiling Point 423.4ºC at 760mmHg
Melting Point 172-173 °C(lit.)
Molecular Formula C15H18O3
Molecular Weight 246.30200
Flash Point 189.7ºC
Exact Mass 246.12600
PSA 43.37000
LogP 2.41960
Vapour Pressure 2.24E-07mmHg at 25°C
Index of Refraction -172.5 ° (C=2, CHCl3)
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LE3150000
CHEMICAL NAME :
Eudesma-1,4-dien-12-oic acid, 6-alpha-hydroxy-3-oxo-, gamma-lactone, (11S)-
CAS REGISTRY NUMBER :
481-06-1
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C15-H18-O3
MOLECULAR WEIGHT :
246.33
WISWESSER LINE NOTATION :
T B566 COV LV IHTT&J E1 I1 M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,301,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 52,79S,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02213 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4536 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 7 (estimated)

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H302-H310-H315-H319-H330-H335
Precautionary Statements P260-P280-P284-P302 + P350-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn
Risk Phrases R22
Safety Phrases S22-S24/25
RIDADR 2811
WGK Germany 3
RTECS LE3150000
Packaging Group II
Hazard Class 6.1(a)

 Articles27

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The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands.

J. Neurosci. 33(1) , 201-13, (2013)

Bitter taste is a basic taste modality, required to safeguard animals against consuming toxic substances. Bitter compounds are recognized by G-protein-coupled bitter taste receptors (TAS2Rs). The huma...

Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones.

Pharmacol. Biochem. Behav. 89(2) , 160-70, (2008)

Here we report the prevention and reversal of cocaine-induced behaviors in planarian worms by parthenolide and two related cyclic sesquiterpene lactones (SL), costunolide and santonin. Using establish...

Diminutive effect on T and B-cell proliferation of non-cytotoxic α-santonin derived 1,2,3-triazoles: a report.

Eur. J. Med. Chem. 60 , 365-75, (2013)

α-Santonin derived new series of 1,2,3-triazoles synthesized through Azide-Alkyne Huisgen 1,3-dipolar cycloaddition reaction between substituted aryl azide and a propargylated α-desmotrosantonin were ...

 Synonyms

Semenen
EINECS 207-560-7
l-Santonin
A-SANTONIN
(3S,3aS,5aS,9bS)-3a,5,5a,9b-tetrahydro-3,5a,9-trimethylnaphtho[1,2-b]furan-2,8(3H,4H)-dione
MFCD00135865
alpha-santonin
(3S,3aS,5aS,9bS)-3,5a,9-trimethyl-3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione
SANTONIN
SANTONIN,A
(3S,5aS,9bS)-3a,5,5a,9b-Tetrahydro-3,5a,9-trimethylnaphtho[1,2-b]furan-2,8(3H,4H)dione
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