tans-4-Hydroxy-D-proline methyl ester hydrochloride

Modify Date: 2024-01-09 18:22:11

tans-4-Hydroxy-D-proline methyl ester hydrochloride structure	Common Name	tans-4-Hydroxy-D-proline methyl ester hydrochloride
	CAS Number	481704-21-6	Molecular Weight	181.617
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆H₁₂ClNO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of tans-4-Hydroxy-D-proline methyl ester hydrochloride

tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

Name	(2R,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylatehydrochloride
Synonym	More Synonyms

Description	tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Molecular Formula	C₆H₁₂ClNO₃
Molecular Weight	181.617
Exact Mass	181.050568
PSA	58.56000
LogP	0.01300

L-Hydroxyproline structure

L-Hydroxyproline

CAS#:3398-22-9

~85%

tans-4-Hydroxy-D-proline methyl ester hydrochloride Structure

tans-4-Hydroxy-...

CAS#:481704-21-6

Literature: WO2003/104249 A1, ; Page 14 ;

(2R,4S)-methyl 4-hydroxy-1-tritylpyrrolidine-2-carboxylate structure

(2R,4S)-methyl ...

CAS#:647857-51-0

~%

tans-4-Hydroxy-D-proline methyl ester hydrochloride Structure

tans-4-Hydroxy-...

CAS#:481704-21-6

Literature: WO2004/7444 A2, ; Page 141 ;

Methanol structure

Methanol

CAS#:67-56-1

tans-4-Hydroxy-D-proline hydrochloride structure

tans-4-Hydroxy-...

CAS#:142347-81-7

~%

tans-4-Hydroxy-D-proline methyl ester hydrochloride Structure

tans-4-Hydroxy-...

CAS#:481704-21-6

Literature: WO2013/49164 A1, ; Paragraph 838-839 ;

Precursor 4
CAS#:3398-22-9 L-Hydroxyproline CAS#:647857-51-0 (2R,4S)-methyl ... CAS#:67-56-1 Methanol CAS#:142347-81-7 tans-4-Hydroxy-...
DownStream 0

Trans-4-hydroxy-L-proline methyl ester hydrochloride

1-Hydroxy-pentan-2-on

Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1)

1-hydroxy-pentan-2-one

Hydroxymethyl-propyl-keton

1-Hydroxy-2-pentanone

2-Pentanone,1-hydroxy

l-hydroxy-2-oxopentane

L-hydroxyproline methyl ester hydrochloride

L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1)

4S-hydroxy-1-pyrrolidine-2R-carboxylic acid methyl ester hydrochloride salt

1-hydroxy-2-oxopentane

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China
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China
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China
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China
Product Name: tans-4-Hydroxy-D-proline methyl ester hydrochloride
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