Dictamnine

Modify Date: 2024-01-03 13:12:46

Dictamnine structure	Common Name	Dictamnine
	CAS Number	484-29-7	Molecular Weight	199.205
	Density	1.3±0.1 g/cm3	Boiling Point	343.2±22.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₉NO₂	Melting Point	133.5ºC
	MSDS	N/A	Flash Point	161.4±22.3 °C

Use of Dictamnine

Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.IC50 value:Target: Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml [1]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis [2].

Name	4-methoxyfuro[2,3-b]quinoline
Synonym	More Synonyms

Description	Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.IC50 value:Target: Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml [1]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis [2].
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Infection
References	[1]. Guo N, et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine. Yeast. 2008 Sep;25(9):631-41. [2]. An FF, et al. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells. Asian Pac J Cancer Prev. 2013;14(10):5895-900.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Natural Products >> Alkaloid

Research Areas >> Infection

References

[1]. Guo N, et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine. Yeast. 2008 Sep;25(9):631-41.

[2]. An FF, et al. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells. Asian Pac J Cancer Prev. 2013;14(10):5895-900.

Density	1.3±0.1 g/cm3
Boiling Point	343.2±22.0 °C at 760 mmHg
Melting Point	133.5ºC
Molecular Formula	C₁₂H₉NO₂
Molecular Weight	199.205
Flash Point	161.4±22.3 °C
Exact Mass	199.063324
PSA	35.26000
LogP	2.94
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.672
Storage condition	-20℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV2709700

CHEMICAL NAME :: Furo(2,3-b)quinoline, 4-methoxy-

CAS REGISTRY NUMBER :: 484-29-7

BEILSTEIN REFERENCE NO. :: 0176932

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H9-N-O2

MOLECULAR WEIGHT :: 199.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 ug/plate

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,349,1988

Hazard Codes	N

Precursor 10
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DownStream 7
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