Dictamnine

Modify Date: 2025-08-20 08:32:46

Dictamnine Structure
Dictamnine structure
 Common Name Dictamnine
CAS Number 484-29-7 Molecular Weight 199.205
Density 1.3±0.1 g/cm3 Boiling Point 343.2±22.0 °C at 760 mmHg
Molecular Formula C12H9NO2 Melting Point 133.5ºC
MSDS N/A Flash Point 161.4±22.3 °C

 Use of Dictamnine


Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.IC50 value:Target: Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml [1]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis [2].

 Names

Name 4-methoxyfuro[2,3-b]quinoline
Synonym More Synonyms

 Dictamnine Biological Activity

Description Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.IC50 value:Target: Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml [1]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis [2].
Related Catalog
References

[1]. Guo N, et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine. Yeast. 2008 Sep;25(9):631-41.

[2]. An FF, et al. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells. Asian Pac J Cancer Prev. 2013;14(10):5895-900.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 343.2±22.0 °C at 760 mmHg
Melting Point 133.5ºC
Molecular Formula C12H9NO2
Molecular Weight 199.205
Flash Point 161.4±22.3 °C
Exact Mass 199.063324
PSA 35.26000
LogP 2.94
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.672
InChIKey WIONIXOBNMDJFJ-UHFFFAOYSA-N
SMILES COc1c2ccccc2nc2occc12
Storage condition -20℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LV2709700
CHEMICAL NAME :
Furo(2,3-b)quinoline, 4-methoxy-
CAS REGISTRY NUMBER :
484-29-7
BEILSTEIN REFERENCE NO. :
0176932
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H9-N-O2
MOLECULAR WEIGHT :
199.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
1 ug/plate
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,349,1988

 Safety Information

Hazard Codes N

 Synthetic Route

 DictamnineBioassay

View more

Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
Name: Half life in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B
Source: ChEMBL
Target: N/A
External Id: CHEMBL5037599
Name: Stability in mouse blood assessed as compound remaining measured at - 80 degC for 4 m...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5037598
Name: Stability in mouse blood assessed as compound remaining measured at 20 degC for 8 hrs
Source: ChEMBL
Target: N/A
External Id: CHEMBL5037597
Name: Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E...
Source: NCGC
External Id: epac1-activator-v
Name: Stability in mouse blood assessed as compound recovery measured at 25 degC for 4 hrs
Source: ChEMBL
Target: N/A
External Id: CHEMBL5037596
Name: Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 3...
Source: NCGC
External Id: epac1-inhibitor-v
Name: Volume of distribution in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B
Source: ChEMBL
Target: N/A
External Id: CHEMBL5037603
Name: AUC (0 to infinity) in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B
Source: ChEMBL
Target: N/A
External Id: CHEMBL5037602
Name: AUC (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B
Source: ChEMBL
Target: N/A
External Id: CHEMBL5037601
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 Synonyms

4-methoxyfuro[2,3-b]quinoline
Dictamine
Dictamnine
4-Methoxy-furo[2,3-b]quinoline
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Chemsrc provides Dictamnine(CAS#:484-29-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Dictamnine are included as well.>> amp version: Dictamnine

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